{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:57:55Z","timestamp":1790359075618,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This world outbreak of Monkeypox (MPX) infections outside Africa emerged on May 2022 in Europe and spread worldwide with unique characteristics: inter\u2010human contagion and infection in men without specific previous immunization, prevalently men\u2010who\u2010have\u2010sex\u2010with\u2010men\u00a0(MSM). Phylogenetic analysis confirmed a unique clade, the West African clade, subclade IIb. On August 30, WHO stated 48\u2009895 laboratory confirmed cases from 101 different countries, of which 28\u2009050 were in Europe. It has therefore become important to define new epidemiological indices. Starting from our new surveillance system EpiMPX open data, we defined an early R\n                    <jats:sub>0<\/jats:sub>\n                    measure, using European ECDC confirmed cases from the epidemic start to the end of August 2022; our early R\n                    <jats:sub>0<\/jats:sub>\n                    pooled median is 2.44, with high variability between countries. We observed the higher R\n                    <jats:sub>0<\/jats:sub>\n                    in Portugal and Germany, followed by Italy, Spain, and France. Anyway, these high estimates refer to the MSM group rather than to the general population. Early estimation of R\n                    <jats:sub>0<\/jats:sub>\n                    can be used to support the epidemiological understanding of transmission dynamics and contain MPX from spreading in naive populations and core groups with risk factors. MPX is in an evolving situation with much to learn and to do to combat the current epidemic outbreak.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28270","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:09:35Z","timestamp":1667347775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Monkeypox: Early estimation of basic reproduction number R\n                    <sub>0<\/sub>\n                    in Europe"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-3877","authenticated-orcid":false,"given":"Francesco","family":"Branda","sequence":"first","affiliation":[{"name":"Department of Computer Science, Modeling, Electronics and Systems Engineering (DIMES) University of Calabria Rende Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-3756","authenticated-orcid":false,"given":"Massimo","family":"Pierini","sequence":"additional","affiliation":[{"name":"EpiData.it Bergamo Italy"},{"name":"Statistics and Big Data Universitas Mercatorum Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-5492","authenticated-orcid":false,"given":"Sandra","family":"Mazzoli","sequence":"additional","affiliation":[{"name":"EpiData.it Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Trends","author":"2022 Monkeypox Outbreak","year":"2022"},{"key":"e_1_2_9_3_1","unstructured":"European Centre for Disease Prevention and Control\/WHO Regional Office for Europe. Monkeypox joint epidemiological overview;2022.\u00a0Accessed\u00a0August 31 \u00a02022.\u00a0https:\/\/monkeypoxreport.ecdc.europa.eu\/"},{"key":"e_1_2_9_4_1","unstructured":"Monkeypox: experts give virus variants new names.\u00a02022. Accessed August 12 2022.https:\/\/www.who.int\/news\/item\/12-08-2022-monkeypox--experts-give-virus-variants-new-names"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01907-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","unstructured":"IsidroJ BorgesV PintoM et al.\u00a02022. Addendum: phylogenomic characterization and signs of microevolution in the multi\u2010country outbreak of monkeypox virus. Nature medicine.","DOI":"10.1038\/s41591-022-02036-2"},{"key":"e_1_2_9_7_1","volume-title":"Monkeypox: New Clinical Symptoms are Identified in Confirmed Cases","author":"Wise J","year":"2022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28099"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt133"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-12-147"},{"key":"e_1_2_9_11_1","article-title":"Monkeypox: EpiMPX surveillance system and open\u2010data with a special focus on European and Italian epidemic","volume":"2","author":"Branda F","year":"2022","journal-title":"J\u00a0Clin\u00a0Virol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"GuzzettaG MammoneA FerraroF. Early estimates on monkeypox incubation period generation time and reproduction number in Italy May\u2010June 2022.\u00a02022","DOI":"10.3201\/eid2810.221126"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.19.242347"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.36.2200675"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081773"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00513-8"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:44:05Z","timestamp":1772959445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jmv.28270"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28270","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]},"assertion":[{"value":"2022-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28270"}}