{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:09:38Z","timestamp":1772982578769,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human herpesvirus (HHV)\u20106 and HHV\u20107 have been detected in central nervous system and glioma tissue, while their exact role in glioma remains uncertain. Omics profiles and clinical information were downloaded from public databases, including The Cancer Genome Atlas cohort for training set and the Chinese Glioma Genome Atlas cohorts for validation sets. Differentially expressed genes between HHV\u20106 and HHV\u20107 infected or noninfected glioma patients were screened for establishing the HHV\u20106 and HHV\u20107 infection (HI) model through Lasso regression analysis. Bioinformatics methods were used to analyze the correlation between HI scores and prognosis, metastasis in glioma patients. Predictable efficacy of HI in temozolomide\u2010resistance and HI\u2010related genetic signatures were also explored. The HI model was constructed as: Risk score\u2009=\u2009(0.014709*DIRAS3)\u2009+\u2009(0.029787*TEX26)\u2009+\u2009(0.223492*FBXO39)\u2009+\u2009(0.074951*MYBL1)\u2009+\u2009(0.060202*HILS1). The five gene signature showed good performance in predicting survival time for glioma patients, while higher HI score is correlated with malignant features. Moreover, DNA mismatch repair genes were augmented in glioma patients with higher HI score as well as nonresponse to temozolomide treatment, which was in parallel with the transcriptomic result of temozolomide\u2010resistant glioma cell. Targeting the five gene signature is beneficial for prognosis of glioma patients, especially in glioma patients underwent temozolomide treatment.<\/jats:p>","DOI":"10.1002\/jmv.28285","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T02:24:55Z","timestamp":1667960695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive analysis of HHV\u20106 and HHV\u20107\u2010related gene signature in prognosis and response to temozolomide of glioma"],"prefix":"10.1002","volume":"95","author":[{"given":"Luoyi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Medical Centre Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengwan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Center &amp; Cancer Clinical Research Center, Sichuan Cancer Hospital &amp; Institute, School of Medicine University of Electronic Science and Technology of China Chengdu 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