{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:10:12Z","timestamp":1772982612753,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recurrent respiratory papillomatosis is strictly connected with human papillomavirus (HPV) infection of the epithelium of the upper respiratory tract. The main treatment of lesions located in the larynx or lower pharynx includes microsurgical excision by using a\u00a0CO\n                    <jats:sub>2<\/jats:sub>\n                    laser. To decrease the amount of surgical procedures gain in importance combined therapy with antiviral agents. The aim of this study was to investigate the effect of the intralesional application of Cidofovir on the tissue of laryngeal papillomas. We have shown that simultaneous microsurgery with adjuvant therapy of Cidofovir reduces chronic inflammation (by measuring the expression of CD4 and CD8 in tissue samples), cell proliferation, and regulates the cell cycle of HPV\u2010infected cells by reducing the expression of p53 and p63 proteins. In addition, this strategy reduces the multiple surgical procedures and regrowth of the pathology.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28303","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T03:40:13Z","timestamp":1668224413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of immunomodulation and regulation of cell cycle in epithelium and stroma after Cidofovir injection in patients with recurrent respiratory papillomatosis\u2014Pilot study"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-3619","authenticated-orcid":false,"given":"Pawe\u0142","family":"Solarz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Laryngological Oncology and Maxillofacial Surgery University Hospital No. 2 Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Gynaecology and Gynaecologic Oncology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"},{"name":"Chair of Pathology University Hospital No. 2 im. Dr. Jan Biziel in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Czech","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Laryngological Oncology and Maxillofacial Surgery University Hospital No. 2 Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Mackiewicz\u2013Nartowicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Laryngological Oncology and Maxillofacial Surgery University Hospital No. 2 Bydgoszcz Poland"},{"name":"Department of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sinkiewicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Szylberg","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Gynaecology and Gynaecologic Oncology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"},{"name":"Chair of Pathology University Hospital No. 2 im. Dr. Jan Biziel in Bydgoszcz Bydgoszcz Poland"},{"name":"Department of Tumor Pathology and Pathomorphology Oncology Centre\u2010Prof. Franciszek \u0141ukaszczyk Memorial Hospital Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u0119drzej","family":"Borowczak","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Gynaecology and Gynaecologic Oncology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Rutkiewicz","sequence":"additional","affiliation":[{"name":"Chair of Pathology University Hospital No. 2 im. Dr. Jan Biziel in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Zwierz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Laryngological Oncology and Maxillofacial Surgery University Hospital No. 2 Bydgoszcz Poland"},{"name":"Department of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Burduk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Laryngological Oncology and Maxillofacial Surgery University Hospital No. 2 Bydgoszcz Poland"},{"name":"Department of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum Nicolaus Copernicus University in Bydgoszcz Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11111279"},{"issue":"6","key":"e_1_2_9_3_1","first-page":"375","article-title":"Recurrent respiratory papillomatosis by HPV: review of the literature and update on the use of cidofovir","volume":"34","author":"Fusconi M","year":"2014","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13387"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07388-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1599-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.4029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5935\/1808-8694.20130114"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13337-017-0382-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.7.977"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205206"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0591"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.02.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0658-0"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:50:15Z","timestamp":1772959815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jmv.28303"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28303","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]},"assertion":[{"value":"2022-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28303"}}