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Herein, we describe the screening and identification of 3\u2010aryl\u2010quinolin\u20102\u2010one derivatives as a novel class of antiviral agents. The 3\u2010aryl\u2010quinolinone derivatives were synthesized via an efficient copper\u2010catalyzed reaction cascade that we previously developed. Using this synthetic method, preliminary structure\u2013activity relationships of this scaffold against the influenza A virus infection were systematically explored. The most potent compound\n                    <jats:bold>34<\/jats:bold>\n                    displayed IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 2.14 and 4.88\u2009\u03bcM against the replication of H3N2 (A\/HK\/8\/68) and H1N1 (A\/WSN\/33) strains, respectively, without apparent cytotoxicity on MDCK cells. We further demonstrated that\n                    <jats:bold>27<\/jats:bold>\n                    and\n                    <jats:bold>34<\/jats:bold>\n                    potently inhibited the plaque formation of the IAV, rendering this scaffold attractive for pursuing novel anti\u2010influenza agents.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28327","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T01:11:45Z","timestamp":1669165905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Screening and identification of 3\u2010aryl\u2010quinolin\u20102\u2010one derivatives as antiviral agents against influenza A"],"prefix":"10.1002","volume":"95","author":[{"given":"Huimin","family":"Cheng","sequence":"first","affiliation":[{"name":"XtalPi Inc. (Shenzhen Jingtai Technology Co., Ltd) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbing","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology, Guangzhou International Campus  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujian","family":"Yang","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Studies and Department of Chemistry Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhening","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology, Guangzhou International Campus  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Wan","sequence":"additional","affiliation":[{"name":"Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchao","family":"Tu","sequence":"additional","affiliation":[{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), School of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-1811","authenticated-orcid":false,"given":"Yingjun","family":"Li","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Studies and Department of Chemistry Southern University of Science and Technology  Shenzhen China"},{"name":"State Key Laboratory of Chemical Oncogenomics Tsinghua Shenzhen International Graduate School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/591853"},{"key":"e_1_2_9_3_1","unstructured":"WHOEMRO. 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