{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:05:43Z","timestamp":1772982343535,"version":"3.50.1"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Analysis of host genetic polymorphisms is an increasingly important tool for understanding and predicting pathogenesis and treatment response of viral diseases. The gene locus of scavenger receptor class B type I (SR\u2010BI), encoding a cell entry factor and receptor for hepatitis C virus (HCV), contains several genetic polymorphisms.\u00a0We applied a probe extension assay to determine the frequency of six single nucleotide polymorphisms (SNPs)\u00a0within the SR\u2010BI gene locus in 374 individuals with history of HCV infection. In addition, SR\u2010BI\u00a0messenger RNA (mRNA) levels were analyzed in liver biopsy specimens of chronically infected HCV subjects.\u00a0The rs5888 variant allele T was present at a higher frequency in subjects with advanced fibrosis (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) and after adjusting for age, duration of infection and alcohol intake as confounding factors. Haplotype analysis of SNP\u00a0frequencies showed that a haplotype consisting of rs61932577 variant allele C and rs5888 variant allele T was associated with an increased risk of advanced liver fibrosis (defined by an Ishak score 4\u22126) (adjusted odds ratio 2.81; 95% confidence interval\u00a01.06\u22127.46.\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038). Carriers of the rs5888 variant allele T displayed reduced SR\u2010BI mRNA expression in liver biopsy specimens.\u00a0In conclusion the rs5888 polymorphism variant is associated with decreased SR\u2010BI expression and an increased risk of development of advanced fibrosis in chronic HCV infection. These findings provide further evidence for a role of SR\u2010BI in HCV pathogenesis and provides a genetic marker for prediction of those infected individuals at greater risk of developing severe disease.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28331","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:12:29Z","timestamp":1669162349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Scavenger receptor class B type I genetic variants associated with disease severity in chronic hepatitis C virus infection"],"prefix":"10.1002","volume":"95","author":[{"given":"Victoria L.","family":"Arandhara","sequence":"first","affiliation":[{"name":"School of Life Sciences, The University of Nottingham Queen's Medical Centre  Nottingham 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the Nottingham University Hospitals NHS Trust and University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Chappell","sequence":"additional","affiliation":[{"name":"School of Life Sciences, The University of Nottingham Queen's Medical Centre  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Life Sciences, The University of Nottingham Queen's Medical Centre  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Baumert","sequence":"additional","affiliation":[{"name":"Institut de Recherche sur les Maladies Virales et H\u00e9patiques Universit\u00e9 de Strasbourg, Inserm  Strasbourg France"},{"name":"IHU Strasbourg, P\u00f4le h\u00e9pato\u2010digestif, H\u00f4pitaux Universitaires de Strasbourg  Strasbourg 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