{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:05:04Z","timestamp":1772982304822,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In Egypt, hepatocellular carcinoma (HCC) ranks as the second largest cause of cancer mortality. PRDM1 is a tumor suppressor gene essential for the differentiation and regulation activity of plasma cells and T cells. It plays a vital role in T cell exhaustion of chronic viral infection and HCC. We aimed to study the role of PRDM1 gene polymorphism in HCV and HCC\u2010related to hepatitis C virus (HCV) progress in Egyptians. The\u00a0case\u2010control study included 300 Egyptian patients divided into\u00a0100 HCC,100 cirrhosis, and 100 control. Laboratory investigations were done for some clinicopathological biomarkers, including liver function tests,\u00a0complete blood picture,\u00a0serum alpha\u2010fetoprotein, and hepatitis markers (HBsAg, anti\u2010HCV\u2010Ab). TaqMan allelic discrimination assay technique was used to genotype PRDM1 gene polymorphism. Multivariant analysis (logistic regression) assessed the association between the polymorphisms with HCC progression and designed the\u00a0suggested model for HCC prediction.\u00a0The frequencies of the G allele and GG phenotype in the control\u00a0group were significantly more than that of the HCC and cirrhosis group. However,\u00a0GA genotypes and A allele frequencies significantly increased in the HCC patients than in cirrhosis and controls. In addition, by comparing the HCC group and the non\u2010HCC group (controls and cirrhotic patients), the subjects carrying AA or GA have 2 times more risk to develop HCC than those carrying GG genotypes (odd ratio\u2009=\u20092.045% and 95%\u00a0confidence interval\u00a0are (1.123\u22123.722)\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019). Multivariate analysis results suggested a model of Aspartate transaminase (AST), Albumin, and PRDM1 polymorphism to predict\u00a0the risk of HCC in Egyptians. In addition, PRDM1 polymorphism has an association with HCC prognosis (tumor size).\u00a0For PRDM1 polymorphism, the A allele and AA might be considered as HCC\u2010related to the\u00a0HCV risk factor. In addition, AST, Albumin, and PRDM1 polymorphism predict\u00a0the risk of HCC in Egyptians Therefore, the polymorphism might help in identifying the susceptible Egyptians to HCC. In addition, polymorphism might have a role in HCC prognosis.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28343","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T22:33:45Z","timestamp":1669329225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of PRDM1 gene polymorphism in the progression of hepatocellular carcinoma in Egyptian patients"],"prefix":"10.1002","volume":"95","author":[{"given":"Amal Ahmed","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Biochemistry National Hepatology and Tropical Medicinal Research Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omnia Ezzat","family":"Esmail","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University  Badr Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya Mohamed Ahmed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University  Badr Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Makled","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department National Hepatology and Tropical Medicine Research institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Al\u2010Hussain","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology, Faculty of Medicine Cairo university Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Elsaid","sequence":"additional","affiliation":[{"name":"Diagnostic and interventional radiology National Hepatology and Tropical Medicinal Research Institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-9822","authenticated-orcid":false,"given":"Mohamed","family":"Alboraie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab R.","family":"El\u2010Awady","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Al\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcar.JCar_9_16"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.068"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05537-2"},{"issue":"3","key":"e_1_2_9_5_1","first-page":"14","article-title":"HCC 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