{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:44:27Z","timestamp":1788864267572,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Globally, 390 million people are at risk of dengue infection and over the past 50 years, the virus incidence increased thirty\u2010fold. In Senegal, an unprecedented occurrence of outbreaks and sporadic cases have been noticed since 2017. In October 2018, an outbreak of Dengue virus 2 (DENV\u20102) was reported in the north of Senegal affecting multiple areas including Saint\u2010Louis, Richard Toll, and Rosso which are located at the border with Mauritania. Of these 173 blood specimen samples collected from patients, 27 were positive for dengue by\u00a0quantitative reverse transcription PCR (qRT\u2010PCR), and eight were serologically confirmed to be positive for DENV immunoglobulin M (IgM). Serotyping using qRT\u2010PCR reveals that isolates were positive for DENV\u20102. A subset of DENV\u20102 positive samples was selected and subjected to whole\u2010genome sequencing followed by phylogenetic analysis. Analysis of six nearly complete genome sequences revealed that the isolates belong to the cosmopolitan genotype and are closely related to the Mauritanian strains detected between 2017 and 2018 and those detected in many West African countries such as Burkina Faso or Cote d'Ivoire. Our results suggest a transboundary circulation of the DENV\u20102 cosmopolitan genotype between Senegal and Mauritania and call for a need for coordinated surveillance of arboviruses between these two countries. Interestingly, a high level of homology between West African isolates highlights endemicity and calls for the set\u2010up of subregional viral genomic surveillance which will lead to a better understanding of viral dynamics, transmission, and spread across Africa.<\/jats:p>","DOI":"10.1002\/jmv.28347","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:11:32Z","timestamp":1669335092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular characterization of circulating Dengue virus 2 during an outbreak in Northern Senegal's Saint\u2010Louis region in 2018"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-5592","authenticated-orcid":false,"given":"Idrissa","family":"Dieng","sequence":"first","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mignane","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Henriette Dior","family":"Ndione","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safietou","family":"Sankhe","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa Mo\u00efse","family":"Diagne","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samba Niang","family":"Sagne","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubacry","family":"Gaye","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamilatou","family":"Balde","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliou","family":"Barry","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamou","family":"Fall","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou Alpha","family":"Sall","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheikh","family":"Loucoubar","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumar","family":"Faye","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousmane","family":"Faye","sequence":"additional","affiliation":[{"name":"Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Global strategy for dengue prevention and control 2012\u20102020.World Health Organization;2012. 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