{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:04:52Z","timestamp":1772982292855,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The purpose of this study is to investigate the production of both severe acute respiratory syndrome\u00a0coronavirus\u20102 (SARS\u2010CoV\u20102)\u2010specific antibodies and autoantibodies in serum following the third booster vaccination of the inactivated COVID\u201019 vaccine, and to study the effect of B cell subsets with CD27 and CD38 phenotypes in peripheral blood on antibody production.\u00a0Routine blood indexes, SARS\u2010CoV\u20102 antibodies, platelet factor 4 and seven antiphospholipid antibodies were detected both before and 2 months after vaccination in the medical staff of the Zhongnan Hospital of Wuhan University. Peripheral blood B cell subtypes were detected before vaccination.\u00a0Following immunization, the positive rate of anti\u2010N\u2010S1 immunoglobulin (IgG) had increased from 24.8% to 91.3% and the average antibody concentration had increased by 11 times. The positive rate of neutralizing antibody\u00a0had increased from 24.8% to 91.3%, the average antibody concentration had increased by 12 times, and the primary increased anti\u2010S1 IgG subtype was that of IgG1. Peripheral blood CD27\u2009+\u2009CD38+\u00a0B cells were positively correlated with antibody levels after vaccination and were a predictor of the antibody response. In addition, although some indicators showed slight absolute changes, the blood parameters and antiphospholipid antibodies of most volunteers were normal both before and after COVID\u201019 inactivated vaccine inoculation, and there was no statistical difference in abnormal rates either before or after inoculation.\u00a0Antibodies in vivo were increased after vaccination with the inactivated vaccine, and IgG1 was the main subtype involved in response to the vaccine. Vaccination with the inactivated COVID\u201019 vaccine did not appear to affect thrombus\u2010related autoantibodies.<\/jats:p>","DOI":"10.1002\/jmv.28356","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:13:05Z","timestamp":1669687985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The third inactivated vaccine booster dramatically enhanced SARS\u2010CoV\u20102 antibody responses and did not influence the profile of prothrombotic antibody"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-2945","authenticated-orcid":false,"given":"Yunbao","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University Wuhan University  Wuhan Hubei China"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment  Wuhan Hubei China"},{"name":"Wuhan Research Center for Infectious Diseases and Tumors of the Chinese Academy of Medical Sciences  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University Wuhan University  Wuhan Hubei China"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University Wuhan University  Wuhan Hubei 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