{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:15:01Z","timestamp":1790766901354,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There are limited data comparing the transmission rates and kinetics of viable virus shedding of the Omicron variant to those of the Delta variant. We compared these rates in hospitalized patients infected with Delta and Omicron variants.\u00a0We prospectively enrolled adult patients with COVID\u201019 admitted to a tertiary care hospital in South Korea between September 2021 and May 2022. Secondary attack rates were calculated by epidemiologic investigation, and daily saliva samples were collected to evaluate viral shedding kinetics. Genomic and subgenomic SARS\u2010CoV\u20102 RNA was measured by PCR, and virus culture was performed from daily saliva samples.\u00a0A total of 88 patients with COVID\u201019 who agreed to daily sampling and were interviewed, were included. Of the 88 patients, 48 (59%) were infected with Delta, and 34 (41%) with Omicron; a further 5\u00a0patients gave undetectable or inconclusive RNA PCR results and 1\u00a0was suspected of being coinfected with both variants. Omicron group had a higher secondary attack rate (31% [38\/124]\u00a0vs.\u00a07% [34\/456],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Survival analysis revealed that shorter viable virus shedding period was observed in Omicron variant compared with Delta variant (median 4, IQR [1\u22127], vs. 8.5 days, IQR [5\u201312 days],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multivariable analysis revealed that moderate\u2010to\u2010critical disease severity (HR: 1.96), and immunocompromised status (HR: 2.17) were independent predictors of prolonged viral shedding, whereas completion of initial vaccine series or first booster\u2010vaccinated status (HR: 0.49), and Omicron infection (HR: 0.44) were independently associated with shorter viable virus shedding.\u00a0Patients with Omicron infections had higher transmission rates but shorter periods of transmissible virus shedding than those with Delta infections.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28369","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T05:06:14Z","timestamp":1669957574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of secondary attack rate and viable virus shedding between patients with SARS\u2010CoV\u20102 Delta and Omicron variants: A prospective cohort study"],"prefix":"10.1002","volume":"95","author":[{"given":"Sung\u2010Woon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heedo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, BK21 Graduate Program Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, College of Medicine Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, BK21 Graduate Program Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, College of Medicine Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euijin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongman","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Oh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Seong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, 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