{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:11:01Z","timestamp":1782353461269,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate the safety of inactivated COVID\u201019 vaccine in Chinese pregnant women and their fetuses when inoculated during the peri\u2010pregnancy period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eligible pregnant women were prospectively collected and divided into a vaccine group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993) and control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009160) according to whether they had been vaccinated against COVID\u201019 within 3 months before their last menstruation period (LMP) and after pregnancy. Demographic data of couples, complications during pregnancy and delivery of pregnant women, and data of newborns at birth were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six women were vaccinated with a median time of 35.5 (range\u2009=\u20090\u201391) days before LMP, and 27 women were vaccinated with a median time of 17 (range\u2009=\u20091\u201372) days after LMP. The incidence of premature rupture of membrane (PROM) in the vaccine group was significantly higher than that in the control group (16.13% vs. 6.88%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). Multivariate logistic regression analysis revealed that maternal peri\u2010pregnancy COVID\u201019 vaccination was not an independent risk factor for PROM (odds ratio: 2.407, 95% confidence interval: 0.932\u20136.216,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.069). There was no difference in the incidence of other complications during pregnancy and delivery between the two groups. A total of 253 neonates were delivered, including two cases with congenital abnormalities in each group. The incidence of congenital abnormalities between the two groups was similar (2.15% vs. 1.25%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.626). There was no difference in neonatal length, weight, head circumference, and Apgar score between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), but the incidence of neonatal jaundice in the vaccine group was significantly higher than that in the control group (20.43% vs. 7.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Multivariate logistic regression analysis revealed that maternal peri\u2010pregnancy vaccination, postpartum blood loss, cesarean section, 1\u2010min Apgar score, and paternal smoking were independent risk factors for neonatal jaundice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is safe for pregnant women and their fetuses to be inoculated the inactivated COVID\u201019 vaccine during the peri\u2010pregnancy period, but attention should be paid to neonatal jaundice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.28378","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T10:49:45Z","timestamp":1670410185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Maternal and neonatal safety of COVID\u201019 vaccination during the peri\u2010pregnancy period: A prospective study"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-5473","authenticated-orcid":false,"given":"Minghui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatology Division 2 Capital Medical University  Beijing Ditan Hospital Beijing China"},{"name":"Department of Hepatology Division 2 Peking University Ditan Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhen","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maternal and Children's Healthcare Hospital of Beijing Dongcheng District  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Capital Medical University  Beijing Ditan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Capital Medical University  Beijing Ditan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Capital Medical University  Beijing Ditan Hospital Beijing China"},{"name":"Department of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Capital Medical University  Beijing Ditan Hospital Beijing 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