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The incremental cost\u2010effectiveness ratio (ICER) was calculated for (1) universal maternal antibody screening with prenatal valacyclovir treatment compared to targeted newborn screening, and (2) universal newborn screening with postnatal valganciclovir treatment compared to targeted newborn screening. We performed a one\u2010way sensitivity analysis.\u00a0Compared to targeted newborn screening, the ICERs for universal newborn screening and maternal screening were 2\u2009966\u2009296 Japanese Yen (JPY) (21\u2009188 USD) and 1\u2009026\u2009984 JPY (7336 USD), respectively. In all scenarios in the one\u2010way sensitivity analysis, the ICERs of the maternal screening and the universal newborn screening strategies were less than three gross domestic product per capita compared with the targeted newborn screening strategy.\u00a0Both maternal and universal newborn screening strategies may be cost\u2010effective than a targeted newborn screening program. The potential utility of the maternal screening with valacyclovir treatment strategy, while potentially cost effective in regions with lower baseline seroprevalence rates, requires further study as the modeling was based on limited evidence.<\/jats:p>","DOI":"10.1002\/jmv.28391","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T06:24:40Z","timestamp":1670567080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The cost\u2010effectiveness of maternal and neonatal screening for congenital cytomegalovirus infection in Japan"],"prefix":"10.1002","volume":"95","author":[{"given":"Hirosato","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara Nara Japan"},{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Bitnun","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Infectious Diseases, The Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-066X","authenticated-orcid":false,"given":"Taito","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara Nara Japan"},{"name":"Department of Health Policy and Management Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.11.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.03.036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.04.022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix344"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-22"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1173"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20736"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13556"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13433"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001599"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1006561"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.11.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2020.03.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.199901"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.10.069"},{"issue":"1","key":"e_1_2_10_21_1","first-page":"1","article-title":"Congenital cytomegalovirus infection in Canada: active surveillance for cases diagnosed by paediatricians","volume":"19","author":"Vaudry W","year":"2014","journal-title":"Paediatr Child Health"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404599"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8101516"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.23949"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.2016"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix621"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240172"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31868-7"},{"key":"e_1_2_10_29_1","unstructured":"Ministry of Health LaW Japan. 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