{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:42:29Z","timestamp":1792190549053,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multiple treatment modalities for Kaposi sarcoma (KS) have been reported, including chemotherapy, radiation therapy, surgical excision, electrochemotherapy, and cryotherapy. Common topical treatments include timolol, imiquimod, and alitretinoin. We searched our institutional database for patients with ICD\u20109 or 10 codes for KS seen by a dermatologist with experience in KS management from July 1, 2004 to January 1, 2022. We screened patient charts to include patients who received combination therapy of cryotherapy followed by topical imiquimod three times a week for 2 months (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099). Patients were followed in the clinic every 3 months. Time to resolution was assessed by photographic evidence of resolution as determined by a dermatologist and corroborated with clinical documentation in patient charts. Median age (IQR) at KS diagnosis was 58 (27.5) years. All patients were male (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099, 100%). Majority were white (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097, 78%) and non\u2010Hispanic (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098, 89%). Five (56%) had classic KS, one (11%) had HIV\u2010associated KS, and three (33%) were HIV\u2010negative men who have sex with men. Median time to resolution was 30.5 weeks, with a median of two treatments. In our study, 93% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200942\/45) of lesions and 89% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098\/9) of patients experienced complete resolution\u00a0during a median (range) duration of follow\u2010up of 58 (13\u2013209) weeks. Side effects were limited to pain during cryotherapy, occasional blister formation after cryotherapy, and mild inflammation due to imiquimod. No infections were observed. Combination therapy of cryotherapy and topical imiquimod may be an efficacious and comparatively low\u2010risk treatment for limited, cutaneous KS.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28396","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:25:09Z","timestamp":1670819109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of immunotherapy with combination of cryotherapy and topical imiquimod for treatment of Kaposi sarcoma"],"prefix":"10.1002","volume":"95","author":[{"given":"Lilly","family":"Gu","sequence":"first","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"},{"name":"Department of Dermatology Weill Cornell Medical College New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Lin","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaitong","family":"Liu","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kurtansky","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Stoll","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Lezcano","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Noor","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Markova","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rossi","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-9342","authenticated-orcid":false,"given":"Liang","family":"Deng","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"},{"name":"Department of Dermatology Weill Cornell Medical College New York City New York USA"},{"name":"Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0060-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14831"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16318"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.11.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12285"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102020-00004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199911010-00004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.041"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00688-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13235"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700777"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-060116-022900"}],"container-title":["Journal 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