{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:57:41Z","timestamp":1792421861586,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accumulation of diverse mutations across the structural and nonstructural genes is leading to rapid evolution of SARS\u2010CoV\u20102, altering its pathogenicity. We performed whole genome sequencing of 239 SARS\u2010CoV\u20102 RNA samples collected from both adult and pediatric patients across eastern India (West Bengal), during the second pandemic wave in India (April\u2013May 2021). In addition to several common spike mutations within the Delta variant, a unique constellation of eight co\u2010appearing non\u2010Spike mutations was identified, which revealed a high degree of positive mutual correlation. Our results also demonstrated the dynamics of SARS\u2010CoV\u20102 variants among unvaccinated pediatric patients. 41.4% of our studied Delta strains harbored this signature set of eight co\u2010appearing non\u2010Spike mutations and phylogenetically out\u2010clustered other Delta sub\u2010lineages like 21J, 21A, or 21I. This is the first report from eastern India that portrayed a landscape of co\u2010appearing mutations in the non\u2010Spike proteins, which might have led to the evolution of a distinct Delta subcluster. Accumulation of such mutations in SARS\u2010CoV\u20102 may lead to the emergence of \u201cvaccine\u2010evading variants.\u201d\u00a0Hence, monitoring of such non\u2010Spike mutations will be significant in the formulation of any future vaccines against those SARS\u2010CoV\u20102 variants that might evade the current vaccine\u2010induced immunity, among both the pediatric and adult populations.<\/jats:p>","DOI":"10.1002\/jmv.28413","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T08:47:19Z","timestamp":1671612439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Emergence of a unique SARS\u2010CoV\u20102 Delta sub\u2010cluster harboring a constellation of co\u2010appearing non\u2010Spike mutations"],"prefix":"10.1002","volume":"95","author":[{"given":"Anindita","family":"Banerjee","sequence":"first","affiliation":[{"name":"National Institute of Biomedical Genomics Kalyani 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