{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:37:07Z","timestamp":1773070627523,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Some viruses, such as varicella zoster virus, are associated with severe dementia. The present study aims to identify the causal link between chickenpox and dementia. To date, the largest publicly available genome\u2010wide association study (GWAS) for chickenpox (710 cases and 211\u2009856 controls from European individuals) and for dementia (5933 cases and 212\u2009859 controls from European individuals) were used to performed this two\u2010sample Mendelian randomization (MR) study. We found no significant pleiotropy or heterogeneity in all seven selected chickenpox genetic instrumental variants in dementia GWAS. Of seven chickenpox genetic variants, two are located in the intergenic region and five are located in intron. We found that as chickenpox genetically increased, dementia risk increased based on an inverse\u2010variance weighted\u00a0analysis (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.070, 95% confidence interval [CI] for\n                    <jats:italic>\u03b2<\/jats:italic>\n                    : 0.014\u20130.126; odds ratio [OR]\u2009=\u20091.073, 95% CI for OR: 1.015\u20131.134;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) and weighted median (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.071, 95% CI for\n                    <jats:italic>\u03b2<\/jats:italic>\n                    : 0.002\u20130.141; OR\u2009=\u20091.074, 95% CI for OR: 1.002\u20131.152;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045). Reverse MR analysis showed no causal effect of dementia on chickenpox. Our analysis suggests a causal effect of genetically increased chickenpox on dementia risk. Thus, chickenpox may be a potential risk factor for dementia.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28420","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T05:28:52Z","timestamp":1671686932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mendelian randomization study on the causal effect of chickenpox on dementia"],"prefix":"10.1002","volume":"95","author":[{"given":"Shan","family":"Zhou","sequence":"first","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaizhi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and 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