{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:43:14Z","timestamp":1790797394500,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human T\u2010cell leukemia virus type 1 (HTLV\u20101) is an oncogenic retrovirus; whereas HTLV\u20101 mainly persists in the infected host cell as a provirus, it also causes a malignancy called adult T\u2010cell leukemia\/lymphoma (ATLL) in about 5% of infection. HTLV\u20101 replication is in most cases silent in vivo and viral de novo infection rarely occurs; HTLV\u20101 rather relies on clonal proliferation of infected T cells for viral propagation as it multiplies the number of the provirus copies. It is mechanistically elusive how leukemic clones emerge during the course of HTLV\u20101 infection in vivo and eventually cause the onset of ATLL. This review summarizes our current understanding of HTLV\u20101 persistence and oncogenesis, with the incorporation of recent cutting\u2010edge discoveries obtained by high\u2010throughput sequencing.<\/jats:p>","DOI":"10.1002\/jmv.28424","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T05:29:50Z","timestamp":1671686990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["HTLV\u20101 persistent infection and ATLL oncogenesis"],"prefix":"10.1002","volume":"95","author":[{"given":"Xiaorui","family":"Zuo","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science China Pharmaceutical University  Nanjing China"},{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoning","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science China Pharmaceutical University  Nanjing China"},{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikai","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science China Pharmaceutical University  Nanjing China"},{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-7201","authenticated-orcid":false,"given":"Guangyong","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science China Pharmaceutical University  Nanjing China"},{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17479.1"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00881-X"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12692-12702.2005"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02719-05"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.897346"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14010152"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00461"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006722"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02735-15"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010416"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014783118"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000788"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02358-14"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00369-17"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8030074"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080115"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009635107"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2065"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.06.188"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006890"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1347"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16963-6"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18874-y"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-016-0249-x"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.016"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30029-9"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-312926"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003271"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-553602"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15264"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0369"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423199113"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36245"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.07.013"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115316119"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316463"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-9-46"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14869"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715724115"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.12469.2"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010387"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.88"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.10.003"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1086\/317932"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-019-0484-z"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507631103"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0044"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009919"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12813-12822.2002"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4551"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001117"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001675"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0942"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445593"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm6210"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017005900"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920346117"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.11.003"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-0405"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3415"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013568"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002665"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014450"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015646"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-662593"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.083"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009219"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14030587"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3169"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.06.014"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005948"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013579"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01062"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0658-4"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13948"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-641118"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/35101031"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002231"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150472"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28424","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:50:13Z","timestamp":1772959813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jmv.28424"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28424","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,28]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28424"}}