{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T09:50:41Z","timestamp":1787478641300,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013275","name":"Instituto Serrapilheira","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The main coronavirus disease 2019 (COVID\u201019) vaccine formulations used today are mainly based on the wild\u2010type severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) spike glycoprotein as an antigen. However, new virus variants capable of escaping neutralization activity of serum antibodies elicited in vaccinated individuals have emerged. The Omicron (B.1.1.529) variant caused epidemics in regions of the world in which most of the population has been vaccinated. In this study, we aimed to understand what determines individual's susceptibility to Omicron in a scenario of extensive vaccination. For that purpose, we collected nasopharynx swab (<jats:italic>n<\/jats:italic>\u2009=\u2009286) and blood samples (<jats:italic>n<\/jats:italic>\u2009=\u2009239) from flu\u2010like symptomatic patients, as well as their vaccination history against COVID\u201019. We computed the data regarding vaccine history, COVID\u201019 diagnosis, COVID\u201019 serology, and viral genome sequencing to evaluate their impact on the number of infections. As main results, we showed that vaccination in general did not reduce the number of individuals infected by Omicron, even with an increased immune response found among vaccinated, noninfected individuals. Nonetheless, we found that individuals who received the third vaccine dose showed significantly reduced susceptibility to Omicron infections. A relevant evidence that support this finding was the higher virus neutralization capacity of serum samples of most patients who received the third vaccine dose. In summary, this study shows that boosting immune responses after a third vaccine dose reduces susceptibility to COVID\u201019 caused by the Omicron variant. Results presented in this study are useful for future formulations of COVID\u201019 vaccination policies.<\/jats:p>","DOI":"10.1002\/jmv.28481","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T08:14:39Z","timestamp":1673079279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The third vaccine dose significantly reduces susceptibility to the B.1.1.529 (Omicron) SARS\u2010CoV\u20102 variant"],"prefix":"10.1002","volume":"95","author":[{"given":"J\u00e9ssica P.","family":"Farias","sequence":"first","affiliation":[{"name":"Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josilene R.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Brazil"},{"name":"Department of Biological Sciences State University of Santa Cruz Ilh\u00e9us Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Andreata\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayanna M. 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