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Hospitalized adults with COVID\u201019 pneumonia and a symptom duration \u226410 days were assigned to 3 arms: imatinib (400\u2009mg qd, 7 days) plus standard\u2010care, baricitinib (4\u2009mg qd, 7 days) plus standard\u2010care, or standard\u2010care alone. Primary outcome was time to clinical improvement (discharge alive or a reduction of 2 points in an ordinal scale of clinical status) compared on a day\u2010by\u2010day basis to identify differences \u226515% between the most and least favorable groups. Secondary outcomes included oxygenation and ventilatory support requirements, additional therapies administered, all\u2010cause mortality, and safety.\u00a0One hundred and sixty\u2010five patients analyzed. Predefined criteria for selection of the most advantageous arm were met for baricitinib, but not for imatinib. However, no statistically significant differences were observed in formal analysis, but a trend toward\u00a0better results in patients receiving baricitinib was found compared to standard care alone (hazard ratio\u00a0[HR]\u00a0for clinical improvement: 1.41, 95%\u00a0confidence intervals\u00a0[CI]: 0.96\u22122.06; HR for discontinuing oxygen: 1.46, 95%\u00a0CI: 0.94\u22122.28). No differences were found regarding additional therapies administered or safety.\u00a0Baricitinib plus standard care showed better results for hospitalized COVID\u201019 patients, being the most advantageous therapeutic strategy among those proposed in this exploratory clinical trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28495","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T07:23:43Z","timestamp":1673681023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Baricitinib or imatinib in hospitalized COVID\u201019 patients: Results from COVINIB, an exploratory randomized clinical trial"],"prefix":"10.1002","volume":"95","author":[{"given":"Alejandro","family":"Morales\u2010Ortega","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario de Fuenlabrada  Madrid Spain"},{"name":"Department of Medicine Universidad de Alcal\u00e1 Madrid 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