{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:48:19Z","timestamp":1761864499638,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In China, most SARS\u2010CoV\u20102\u2010infected individuals had been vaccinated with inactivated vaccines. However, little is known about their immune resistances to the previous variants of concerns (VOCs) and the current Omicron sublineages. Here, we collected convalescent serum samples from SARS\u2010CoV\u20102\u2010infected individuals during the ancestral, Delta, and Omicron BA.1 waves, and evaluated their cross\u2010neutralizing antibodies (nAbs) against the previous VOCs and the current Omicron sublineages using VSV\u2010based pseudoviruses. In the convalescents who had been unvaccinated and vaccinated with two doses of inactivated vaccines, we found infections from either the ancestral or the Delta strain elicited moderate cross\u2010nAbs to previous VOCs, but very few cross\u2010nAbs to the Omicron sublineages, including BA.1, BA.2, BA.3, and BA.4\/5. The individuals who had been vaccinated with two doses of inactivated vaccines before Omicron BA.1 infection had moderate nAbs to Omicron BA.1, but weak cross\u2010nAbs to the other Omicron sublineages. While three doses of inactivated vaccines followed Omicron BA.1 infection induced elevated and still weak cross\u2010nAbs to other Omicron sublineages. Our results indicate that the Omicron sublineages show significant immune escape in the previously SARS\u2010CoV\u20102\u2010infected individuals and thus highlights the importance of vaccine boosters in this population.<\/jats:p>","DOI":"10.1002\/jmv.28516","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T08:04:52Z","timestamp":1674288292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Significant neutralizing escapes of Omicron and its sublineages in SARS\u2010CoV\u20102\u2010infected individuals vaccinated with inactivated vaccines"],"prefix":"10.1002","volume":"95","author":[{"given":"Fan","family":"Shen","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences\/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui\u2010Xian","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Infectious Disease Hospital  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences\/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Infectious Disease Hospital  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-7216","authenticated-orcid":false,"given":"Ren\u2010Rong","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences\/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing\u2010Qi","family":"Dong","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Infectious Disease Hospital  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u2010Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences\/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-0324","authenticated-orcid":false,"given":"Yong\u2010Tang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences\/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Pang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences\/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"issue":"24","key":"e_1_2_10_2_1","first-page":"8019","article-title":"Omicron (B.1.1.529) \u2010 variant of concern \u2010 molecular profile and epidemiology: a mini review","volume":"25","author":"Kannan 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