{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:14:08Z","timestamp":1770272048527,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>No data about antiretroviral (ARV) treatment coverage and virological response are available among key populations (female sex workers [FSW] and Men having Sex with Men [MSM]) in Togo. This study aimed to both describe Human Immunodeficiency Virus (HIV) immunovirological status and evaluate the pertinence of an original algorithm combining pharmacology (PK) and viral load (VL) to identify subjects at risk of ARV drug resistance.\u00a0A cross\u2010sectional multicentric study was conducted in 2017 in Togo. Our PK\u2010virological algorithm (PK\u2010VA) defines subjects at risk of resistance when exhibiting both detectable plasma drug concentrations and VL\u2009&gt;\u2009200 c\/mL.\u00a0Among the 123 FSW and 136 MSM included, 50% and 66% were receiving ARV, with 69% and 80% of them successfully\u2010treated, respectively. Genotypes showed drug\u2010resistance mutation\u00a0in 58% and 63% of nonvirologically controlled (VL\u2009&gt;\u2009200\u2009c\/mL) ARV\u2010treated FSW and MSM, respectively. PK\u2010VA would have enabled to save 75% and 72% of genotypic tests, for FSW and MSM, respectively.\u00a0We reported first data about HIV care cascade among key populations in Togo, highlighting they are tested for HIV but linkage to care remains a concern. Furthermore, 70%\u221280% of ARV\u2010treated participants experienced virological success. In limited resources settings, where genotyping tests are beyond reach, PK\u2010VA might be an easiest solution to sort out patients needing ARV adaptation due to resistance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28535","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:46:05Z","timestamp":1674891965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmaco\u2010virological algorithm to target risk of drug resistance among a population of HIV\u2010infected key populations in Togo"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2196-6141","authenticated-orcid":false,"given":"Valentine M.","family":"Ferr\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Inserm UMR_1137, IAME Paris France"},{"name":"Service de Virologie, AP\u2010HP H\u00f4pital Bichat\u2013Claude Bernard Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra M.","family":"Bitty\u2010Anderson","sequence":"additional","affiliation":[{"name":"Centre Africain de Recherche en Epid\u00e9miologie et en Sant\u00e9 Publique (CARESP) Lom\u00e9 Togo"},{"name":"National Institute for Health and Medical Research (INSERM) UMR 1219 University of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Peytavin","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, AP\u2010HP H\u00f4pital Bichat\u2013Claude Bernard Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh P.","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, AP\u2010HP H\u00f4pital Bichat\u2013Claude Bernard Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claver A.","family":"Dagnra","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lom\u00e9 Centre de Biologie Mol\u00e9culaire et d'Immunologie Lom\u00e9 Togo"},{"name":"Programme national de lutte contre le sida et les infections sexuellement transmissibles Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Copp\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Inserm UMR_1137, IAME Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fifonsi A.","family":"Gbeasor\u2010Komlanvi","sequence":"additional","affiliation":[{"name":"Centre Africain de Recherche en Epid\u00e9miologie et en Sant\u00e9 Publique (CARESP) Lom\u00e9 Togo"},{"name":"D\u00e9partement de Sant\u00e9 Publique, Facult\u00e9 des Sciences de la Sant\u00e9 Universit\u00e9 de Lom\u00e9 Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Descamps","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Inserm UMR_1137, IAME Paris France"},{"name":"Service de Virologie, AP\u2010HP H\u00f4pital Bichat\u2013Claude Bernard Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Inserm UMR_1137, IAME Paris France"},{"name":"Service de Virologie, AP\u2010HP H\u00f4pital Bichat\u2013Claude Bernard Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier K.","family":"Ekouevi","sequence":"additional","affiliation":[{"name":"Centre Africain de Recherche en Epid\u00e9miologie et en Sant\u00e9 Publique (CARESP) Lom\u00e9 Togo"},{"name":"National Institute for Health and Medical Research (INSERM) UMR 1219 University of Bordeaux Bordeaux France"},{"name":"D\u00e9partement de Sant\u00e9 Publique, Facult\u00e9 des Sciences de la Sant\u00e9 Universit\u00e9 de Lom\u00e9 Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Conseil National de Lutte contre le SIDA et les IST. Rapport d'activit\u00e9 sur la riposte au VIH\/SIDA au Togo [Internet]. 2015.https:\/\/www.unaids.org\/sites\/default\/files\/country\/documents\/TGO_narrative_report_2015.pdf"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-022-00851-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1012"},{"key":"e_1_2_11_5_1","first-page":"294","article-title":"Prevalence of HIV infection and hepatitis B and factors associated with them among men who had sex with men in Togo in 2017","volume":"29","author":"Sadio AJ","year":"2019","journal-title":"Med Sante Trop"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.09.011"},{"key":"e_1_2_11_7_1","unstructured":"R\u00e9publique du Togo. Programme National de lutte contre le VIH et les infections sexuellement transmissibles. 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