{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:14:00Z","timestamp":1780514040550,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the ongoing COVID\u201019 pandemic, rapid and reliable detection of SARS\u2010CoV\u20102 is important to enable proper care of patients and to prevent further transmission. The aim of this study was to evaluate the performance of the Roche SARS\u2010CoV\u20102 Rapid Antigen Test (Ag\u2010RDT) in an emergency care setting during a high pandemic period. The analytical performance of the Ag\u2010RDT was compared to real\u2010time reverse transcriptase polymerase chain reaction (rRT\u2010PCR). A total of 132 patient samples, previously analyzed with rRT\u2010PCR, were reanalyzed with the Ag\u2010RDT. Tenfold serial dilutions of five different patient strains containing the pangolin variants BA.1, BA.2, B.1.1.7, B.1.160, and B.1.177 were analyzed in parallel with the Ag\u2010RDT and rRT\u2010PCR. A clinical evaluation was performed in which 1911 consecutive patients admitted to the emergency wards in Region G\u00e4vleborg, Sweden, were included. Paired samples were collected and analyzed with the Ag\u2010RDT on\u2010site and with rRT\u2010PCR at the microbiology laboratory. The overall sensitivity and specificity of the Ag\u2010RDT in the clinical evaluation were 71.3% and 99.7%, respectively. When samples with cycle threshold (Ct) values above 30 were excluded, the sensitivity was 86.5%. Eleven of the admitted patients who were positive for both the Ag\u2010RDT and rRT\u2010PCR (Ct\u2010range 16.9\u201330.4) showed no symptoms of COVID\u201019. Using the Ag\u2010RDT shortened the detection time by an average of 11\u2009h. The Ag\u2010RDT is a useful tool for preliminary screening of SARS\u2010CoV\u20102 because it enables rapid detection in infectious individuals and therefore, can counteract unnecessary spread of infection at an early stage.<\/jats:p>","DOI":"10.1002\/jmv.28537","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T09:44:02Z","timestamp":1675071842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the performance of a rapid antigen test (Roche) for COVID\u201019 diagnosis in an emergency setting in Sweden"],"prefix":"10.1002","volume":"95","author":[{"given":"Anna","family":"Heydecke","sequence":"first","affiliation":[{"name":"Centre for Research and Development Uppsala University\/Region G\u00e4vleborg  G\u00e4vle Sweden"},{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-0483","authenticated-orcid":false,"given":"Karolina","family":"Gullsby","sequence":"additional","affiliation":[{"name":"Centre for Research and Development Uppsala University\/Region G\u00e4vleborg  G\u00e4vle Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. Recommendations for national SARS\u2010CoV\u20102 testing strategies and diagnostic capacities: interim guidance June 25 2021 [Internet]. World Health Organization; 2021. Report No: WHO\/2019\u2010nCoV\/lab_testing\/2021.1. Accessed November 14 2022.\u00a0https:\/\/apps.who.int\/iris\/handle\/10665\/342002"},{"key":"e_1_2_10_3_1","unstructured":"European Centre for Disease Prevention and Control. Options for the use of rapid antigen tests for COVID\u201019 in the EU\/EEA\u2014first update [Internet]. 2021. Accessed November 14 2022.https:\/\/www.ecdc.europa.eu\/en\/publications-data\/options-use-rapid-antigen-tests-covid-19-eueea-first-update"},{"key":"e_1_2_10_4_1","unstructured":"EU Common list of COVID-19 antigen tests [Internet]. Accessed February 2 2023.https:\/\/health.ec.europa.eu\/system\/files\/2023-02\/covid-19_eu-common-list-antigen-tests_en.pdf"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2196-x"},{"key":"e_1_2_10_6_1","unstructured":"World Health Organization. Antigen\u2010detection in the diagnosis of SARS\u2010CoV\u20102 infection: interim guidance October 6 2021 [Internet]. World Health Organization; 2021. Report No: WHO\/2019\u2010nCoV\/Antigen_Detection\/2021.1. Accessed November 14 2022.https:\/\/apps.who.int\/iris\/handle\/10665\/345948"},{"key":"e_1_2_10_7_1","article-title":"Rapid, point\u2010of\u2010care antigen tests for diagnosis of SARS\u2010CoV\u20102 infection","volume":"7","author":"Dinnes J","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.870738"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003735"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"key":"e_1_2_10_11_1","unstructured":"Vecka 8. Statistik om SARS\u2010CoV\u20102 virusvarianter av s\u00e4rskild betydelse\u2014Folkh\u00e4lsomyndigheten [Internet]. 2021. 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