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However, validated tools for systematic assessment of disease severity are lacking. This study aimed at creating and validating a standardized, simple\u2010to\u2010use disease severity score for RSV infection in children\u2014the RSV\u2010CLASS\u00a0(Clinical Assessment Severity Score). Therefore, data from over 700 RSV\u2010infected children over six winter seasons (2014\u20132020) was analyzed using univariate and multiple regression analyses for the prediction of lower respiratory tract infection (LRTI) as a proxy for a severe course of the disease. Testing a broad range of respiratory symptoms, they eventually yielded seven items. Performing stepwise selection, these were reduced to the final four items: cough, tachypnea, rales, and wheezing, each receiving one point in the proposed score named RSV\u2010CLASS. The score was calculated for children in two cohorts A and B, one for development and one for validation, with an area under the curve of 0.90 and 0.87, respectively. With a score value of 3 or 4, 97.8% and 100% of the children, respectively, were admitted with LRTI and classified correctly. The RSV\u2010CLASS is a disease severity score based on a neutral, analytical approach using prospective data from a large study cohort. It will contribute to systematically assessing the disease severity of RSV infection and can be used for evidence\u2010based clinical decision\u2010making as well as for research settings.<\/jats:p>","DOI":"10.1002\/jmv.28541","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T06:48:25Z","timestamp":1675320505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["RSV\u2010CLASS \u2014Clinical Assessment Severity Score: An easy\u2010to\u2010use clinical disease severity score for respiratory syncytial virus infection in hospitalized children"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-4163","authenticated-orcid":false,"given":"Julia","family":"Gsenger","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Virology University Hospital Heidelberg  Heidelberg Germany"},{"name":"German Center for Infectious Diseases 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