{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:20Z","timestamp":1786978040308,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since the start of the pandemic, there has been an increase in the incidence of psychiatric morbidity among those infected with coronavirus disease 2019 (COVID\u201019) and those indirectly affected by COVID\u201019. There has been a considerable increase in the number of individuals with such psychiatric conditions as depression, acute stress disorders, anxiety, and posttraumatic stress disorder (PTSD). About one\u2010third of patients with COVID\u201019 are reported to have developed short and long\u2010term neuropsychiatric conditions such as delirium, agitation, altered consciousness, hypoxic encephalopathy encephalitis, dysexecutive syndrome, cerebrovascular complications (e.g., stroke), hypoxic encephalopathy, convulsions, neuromuscular dysfunction, demyelinating processes, or parkinsonism through several pathophysiological mechanisms. Nevertheless, as the pandemic progressed, data on neuropsychiatric manifestations implied that the pathologic capacity of COVID\u201019 and its association with the onset and\/or exacerbation of psychiatric morbidity indicate that COVID\u201019 is potentially related to neuropsychiatric involvement. Patients with existing mental disorders under psychotropic treatment exposed to the COVID\u201019 infection have been represented by an increased risk of worsened psychiatric symptoms and expanded drug side effects. The present study aimed to describe five pediatric patients with various psychiatric illness that experienced COVID\u201019 infection and had potentially associated neuropsychiatric involvement, such as exacerbation of underlying psychiatric symptoms and extrapyramidal side effects. To the best of our knowledge, the present study is the first to describe adolescents with COVID\u201019 infection that presented with a series of manifestations in the form of an increase in extrapyramidal\u00a0symptoms\u00a0(EPS)\u00a0\u00a0during exacerbation of underlying psychiatric disease.<\/jats:p>","DOI":"10.1002\/jmv.28556","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T06:24:00Z","timestamp":1675491840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Appearance of extrapyramidal symptoms in adolescent psychiatry patients during COVID\u201019 infection"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-5602","authenticated-orcid":false,"given":"Aysegul","family":"Tonyali","sequence":"first","affiliation":[{"name":"Istanbul Bak\u0131rk\u00f6y Prof. Dr. Mazhar Osman Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Karacetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celal","family":"Yesilkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza Nur Tas","family":"Arik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binay","family":"Kayan Ocakoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30203-0"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.581426"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0500"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070970"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.04.027"},{"key":"e_1_2_13_8_1","unstructured":"Clinical Management of COVID\u201019: Interim Guidance 27 May 2020 and Last Updated as \u201cLiving guidance for clinical management of COVID\u201019: The (third) latest version 23 November 2021.\u201d Accessed November 21 2022.https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-clinical-2021-2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.163"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14329"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111200"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.048"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651500310002986"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170003960X"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216010-00003"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2021.100098"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113052"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp052"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27443"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2022.103123"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00193-0"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-020-00530-7"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00652"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30305-7"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010282"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2021.100116"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.03.023"},{"key":"e_1_2_13_28_1","volume-title":"Antipsychotic Drugs","author":"Freudenreich O","year":"2016"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-136"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.06.012"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-020-00123-0"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00737-08"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2992088"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870070210"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202135"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201187"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12677"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00874.x"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10444-6"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02158"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.08.011"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2021.02.006"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.10749"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T08:38:54Z","timestamp":1722587934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/jmv.28556"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28556","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28556"}}