{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:20Z","timestamp":1786978040350,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since May 2022, multiple human Monkeypox cases were identified in nonendemic countries, mainly among men who have sex with men. We aimed to report the features, clinical course, management, and outcome of the Monkeypox cases diagnosed in the Dermatology and Infectious Disease Units of the San Martino Hospital, Genoa, Italy.\u00a0We performed an observational study of the Monkeypox cases diagnosed from July 1 until August 31, 2022, collecting clinical, laboratory, and histological data.\u00a0We studied 16 Monkeypox\u2010infected men (14 homosexual, 2 bisexual) with a median age of 37 years. Three were HIV\u2010infected. All patients reported multiple sexual partners and\/or unprotected sex in the 2 weeks before the diagnosis. Most patients had prodromal signs\/symptoms before the appearance of the skin\/mucosal eruption, consisting of erythematous papules\/vesicles\/pustules in the anogenital area, which tended to erode evolving into crusts and ulcers. Lesions were often associated with local and\/or systemic symptoms. Histopathology showed overlapping features in all cases: epidermal ulceration and dermal inflammatory infiltrate consisting of lymphocytes and neutrophils with an interstitial and perivascular\/peri\u2010adnexal pattern and endothelial swelling. Concomitant sexually transmitted infections\u00a0(STIs) (gonococcal\/nongonococcal proctitis and anal high\u2010risk human papillomavirus [HR\u2010HPV] infection) were frequent. Four patients were hospitalized, and one received specific treatment. The overall outcome was good. At the follow\u2010up visit, three patients presented skin scars.\u00a0Our series confirms the features of the current Monkeypox outbreak; however, different from other studies, we found a considerable rate of concomitant STIs, such as anal HR\u2010HPV infection, that should be kept in mind because this persistent infection is the main cause of anal cancers.<\/jats:p>","DOI":"10.1002\/jmv.28560","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T07:30:01Z","timestamp":1675927801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Monkeypox outbreak in Genoa, Italy: Clinical, laboratory, histopathologic features, management, and outcome of the infected patients"],"prefix":"10.1002","volume":"95","author":[{"given":"Giulia","family":"Ciccarese","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Dermatology University of Foggia Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-5089","authenticated-orcid":false,"given":"Antonio","family":"Di Biagio","sequence":"additional","affiliation":[{"name":"Department of Specialist Medicine, Infectious Disease Clinic IRCCS Ospedale Policlinico San Martino Genoa Italy"},{"name":"Department of Health Sciences, Division of Infectious Diseases University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Bruzzone","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Hygiene Unit IRCCS Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Guadagno","sequence":"additional","affiliation":[{"name":"Pathology Unit, Ospedale Policlinico San Martino University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-6358","authenticated-orcid":false,"given":"Lucia","family":"Taramasso","sequence":"additional","affiliation":[{"name":"Department of Specialist Medicine, Infectious Disease Clinic IRCCS Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Oddenino","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, DISSAL, University of Genoa, Ospedale\u2010Policlinico San Martino IRCCS Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Brucci","sequence":"additional","affiliation":[{"name":"Department of Specialist Medicine, Infectious Disease Clinic IRCCS Ospedale Policlinico San Martino Genoa Italy"},{"name":"Department of Health Sciences, Division of Infectious Diseases University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Labate","sequence":"additional","affiliation":[{"name":"Department of Specialist Medicine, Infectious Disease Clinic IRCCS Ospedale Policlinico San Martino Genoa Italy"},{"name":"Department of Health Sciences, Division of Infectious Diseases University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"De Pace","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Hygiene Unit IRCCS Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mastrolonardo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Dermatology University of Foggia Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-0459","authenticated-orcid":false,"given":"Francesco","family":"Broccolo","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies University of Salento Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Robello","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, DISSAL, University of Genoa, Ospedale\u2010Policlinico San Martino IRCCS Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Drago","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, DISSAL, University of Genoa, Ospedale\u2010Policlinico San Martino IRCCS Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Department of Specialist Medicine, Infectious Disease Clinic IRCCS Ospedale Policlinico San Martino Genoa Italy"},{"name":"Department of Health Sciences, Division of Infectious Diseases University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Parodi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, DISSAL, University of Genoa, Ospedale\u2010Policlinico San Martino IRCCS Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization. Monkeypox. Accessed October 23 2022.\u00a0https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/monkeypox"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010141"},{"key":"e_1_2_9_4_1","unstructured":"European Centre for Disease Prevention and Control. Monkeypox situation update as of 20 September 2022. Accessed October 23 2022.\u00a0https:\/\/www.ecdc.europa.eu\/en\/news-events\/monkeypox-situation-update"},{"key":"e_1_2_9_5_1","unstructured":"Ministero della Salute. Malattie infettive. Vaiolo delle scimmie. Accessed October 23 2022.\u00a0https:\/\/www.salute.gov.it\/portale\/malattieInfettive\/dettaglioSchedeMalattieInfettive.jsp?lingua=italiano%26id=254%26area=Malattie%20infettive%26menu=indiceAZ%26tab=1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102392"},{"key":"e_1_2_9_7_1","unstructured":"World Health Organization. Vaccines and immunization for monkeypox: interim guidance 24 August 2022. 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