{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:58:04Z","timestamp":1753869484976,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005941","name":"Dietmar Hopp Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on cross\u2010neutralization of the SARS\u2010CoV\u20102 omicron variant more than 1 year after SARS\u2010CoV\u20102 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live\u2010virus neutralization of the SARS\u2010CoV\u20102 omicron (BA.1) variant in children compared with adults 14 months after mild or asymptomatic wild\u2010type SARS\u2010CoV\u20102 infection. We also evaluated immunity to reinfection conferred by previous infection plus COVID\u201019 mRNA vaccination. We studied 36 adults and 34 children 14 months after acute SARS\u2010CoV\u20102 infection. While 94% of unvaccinated adults (16\/17) and children (32\/34) neutralized the delta (B.1.617.2) variant, only 1\/17 (5.9%) unvaccinated adults, 0\/16 (0%) adolescents and 5\/18 (27.8%) children &lt;12 years of age had neutralizing activity against omicron (BA.1). In convalescent adults, one or two doses of mRNA vaccine increased delta and omicron neutralization 32\u2010fold, similar to a third mRNA vaccination in uninfected adults. Neutralization of omicron was 8\u2010fold lower than that of delta in both groups. In conclusion, our data indicate that humoral immunity induced by previous SARS\u2010CoV\u20102 wild\u2010type infection more than 1 year ago is insufficient to neutralize the current immune escape omicron variant.<\/jats:p>","DOI":"10.1002\/jmv.28582","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T10:39:50Z","timestamp":1676543990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Live\u2010virus neutralization of the omicron variant in children and adults 14 months after SARS\u2010CoV\u20102 wild\u2010type infection"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-9058","authenticated-orcid":false,"given":"Maximilian","family":"Stich","sequence":"first","affiliation":[{"name":"Department of Pediatrics I University Children's Hospital Heidelberg Heidelberg 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