{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:46:03Z","timestamp":1790315163678,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Herpes simplex virus type 2 (HSV\u20102) infection is a prevalent, sexually transmitted infection with poorly characterized prevalence in the Middle East and North Africa (MENA) region. This study characterized HSV\u20102 epidemiology in MENA. HSV\u20102 reports were systematically reviewed as guided by the Cochrane Collaboration Handbook and findings were reported following PRISMA guidelines. Random\u2010effects meta\u2010analyses and meta\u2010regressions were performed to estimate pooled mean outcome measures and to assess predictors of HSV\u20102 antibody prevalence (seroprevalence), trends in seroprevalence, and between\u2010study heterogeneity. In total, sixty\u2010one overall (133 stratified) HSV\u20102 seroprevalence measures and two overall (four stratified) proportion measures of HSV\u20102 detection in laboratory\u2010confirmed genital herpes were extracted from 37 relevant publications. Pooled mean seroprevalence was 5.1% (95% confidence interval [CI]: 3.6%\u20136.8%) among general populations, 13.3% (95% CI: 8.6%\u201318.7%) among intermediate\u2010risk populations, 20.6% (95% CI: 5.3%\u201342.3%) among female sex workers, and 18.3% (95% CI: 3.9%\u201339.4%) among male sex workers. Compared to Fertile Crescent countries, seroprevalence was 3.39\u2010fold (95% CI: 1.86\u20136.20) and 3.90\u2010fold (95% CI: 1.78\u20138.57) higher in Maghreb and Horn of Africa countries, respectively. Compared to studies published before 2010, seroprevalence was 1.73\u2010fold (95% CI: 1.00\u20132.99) higher in studies published after 2015. Pooled mean proportion of HSV\u20102 detection in genital herpes was 73.8% (95% CI: 42.2%\u201395.9%). In conclusion, MENA has a lower HSV\u20102 seroprevalence than other world regions. Yet, 1 in 20 adults is chronically infected, despite conservative prevailing sexual norms. Seroprevalence may also be increasing, unlike other world regions. Findings support the need for expansion of surveillance and monitoring of HSV\u20102 infection in MENA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.28603","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T05:04:49Z","timestamp":1677128689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Epidemiology of herpes simplex virus type 2 in the Middle East and North Africa: Systematic review, meta\u2010analyses, and meta\u2010regressions"],"prefix":"10.1002","volume":"95","author":[{"given":"Manale","family":"Harfouche","sequence":"first","affiliation":[{"name":"Infectious Disease Epidemiology Group, Weill Cornell Medicine\u2010Qatar, Cornell University Qatar Foundation\u2013Education City  Doha Qatar"},{"name":"World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV\/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine\u2010Qatar, Cornell University Qatar Foundation\u2013Education City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asalah","family":"Alareeki","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology Group, Weill Cornell Medicine\u2010Qatar, Cornell University Qatar Foundation\u2013Education City  Doha Qatar"},{"name":"World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV\/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine\u2010Qatar, Cornell University Qatar Foundation\u2013Education City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha M. 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