{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:24:48Z","timestamp":1785860688421,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>An estimated 1.08 million carriers of human T\u2010lymphotropic virus 1 (HTLV\u20101) were living in Japan in 2006\u20132007. Since that study, new data on horizontal infection, nationwide antenatal screening for anti\u2010HTLV\u20101 in pregnant women, and social educational campaigns on HTLV\u20101 infection have emerged in Japan. To estimate the current number of HTLV\u20101 carriers in Japan, confirmed HTLV\u20101 infections among first\u2010time blood donors in 2020\u20132021 from across Japan were investigated. Age\u2010, sex\u2010 and geographic area\u2010specific information associated with HTLV\u20101 antibody detection was evaluated. Data obtained were compared with predictions based on 2006\u20132007 data, considering a birth cohort effect that assumed lifelong maintenance of seropositivity.\u00a0HTLV\u20101 seroprevalence in women was almost equivalent to that in men. The prevalence in men was similar to that predicted from 2006 to 2007 data. In contrast, the prevalence in women was lower in all age strata than that predicted by each birth cohort. The estimate for the entirety of Japan was 534\u2009000 carriers from measured prevalence, whereas that from the birth cohort effect\u2010adjusted prevalence was 658\u2009000. The number of HTLV\u20101 carriers in Japan was estimated to have decreased by approximately 40% during the past 14 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28606","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T10:04:46Z","timestamp":1677146686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Lower prevalence of anti\u2010HTLV\u20101 as expected by previous models among first\u2010time blood donors in Japan"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-6839","authenticated-orcid":false,"given":"Masahiro","family":"Satake","sequence":"first","affiliation":[{"name":"Japanese Red Cross Central Blood Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Sagara","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kyushu Block Blood Centre Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00388"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01124"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ145"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23181"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30252-3"},{"key":"e_1_2_10_7_1","unstructured":"Japanese Ministry of Health Labour and Welfare. (ItabashiK ed.) Manual for the prevention of mother\u2010to\u2010child transmission of HTLV\u20101\u00a0(in Japanese). Accessed August 17 2022.https:\/\/www.mhlw.go.jp\/bunya\/kodomo\/boshi-hoken16\/dl\/06.pdf"},{"key":"e_1_2_10_8_1","unstructured":"HamaguchiI WatanabeT UchimaruK et al. Guidelines for the diagnosis of HTLV\u20101 infection\u00a0(in Japanese).jsnhd.or.jp\/pdf\/HTLV-1_201912.pdf. Accessed August 17 2022."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30735-7"},{"key":"e_1_2_10_10_1","unstructured":"Ministry of Health Labour and Welfare of Japan.\u00a0(in Japanese).Get accurate knowledge of HTLV\u20101. 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