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Systematic search of PubMed, EMBASE, and CNKI (China National Knowledge Infrastructure) databases without language restriction for studies published before September 19, 2022. The review was registered with PROSPERO (CRD42022335430) and reported according to PRISMA guidelines. Forty studies met the inclusion criteria for this study, with 62\u2009954\u2009861 participants. The overall vaccine effectiveness (VE) to prevent COVID\u201019 infection was 0.76 (95% confidence interval [CI] 0.73\u20130.78), symptomatic infection was 0.87 (95% CI 0.83\u20130.91), hospital admissions was 0.82 (95% CI 0.75\u20130.87), and mortality was 0.76 (95% CI 0.48\u20130.89). Subgroup analysis were performed to characterize the effectiveness of different vaccines. When SARS\u2010CoV\u20102 variants are taking account, the VE decreased along with the variation of the virus by clinical outcomes and vaccine types. The findings of this systematic review provide the best available evidence that BNT162b2, mRNA\u20101273, ChAdOx1, and Ad26. COV2.S seems to be approximately effective from predelta to omicron, but only modestly effective in participants aged 65 or older. When SARS\u2010CoV\u20102 variants are taking account, VE decreased along with the variation of the virus for all mRNA and viral\u2010vector vaccines.<\/jats:p>","DOI":"10.1002\/jmv.28623","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T09:40:20Z","timestamp":1678009220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effectiveness of mRNA and viral\u2010vector vaccines in epidemic period led by different SARS\u2010CoV\u20102 variants: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"95","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Forensic Pathology, West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Forensic Pathology, West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-1940","authenticated-orcid":false,"given":"Kui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Forensic Pathology, West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.06.049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11020129"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108891"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03426-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n579"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.03.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7028e2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03944-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27541"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn4947"},{"key":"e_1_2_8_12_1","unstructured":"Update on Omicron.2022.https:\/\/www.who.int\/news\/item\/28-11-2021-update-on-omicron"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00556-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2102179"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2104974"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/30010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-069761","article-title":"Clinical severity of, and effectiveness of mRNA vaccines against, Covid\u201019 from Omicron, Delta, and Alpha SARS\u2010CoV\u20102 variants in the United States: prospective observational study","volume":"376","author":"Lauring AS","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7104e1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7104e3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7034e4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10030426"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7013e3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021091262"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.7152"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab262"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7038e1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","unstructured":"PuranikA LenehanPJ SilvertE et al. 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