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Most BL cases are characterized by a t(8;14) chromosomal translocation involving the <jats:italic>MYC<\/jats:italic> oncogene and the immunoglobulin heavy chain gene (<jats:italic>IGH<\/jats:italic>). The role of EBV in promoting this translocation remains largely unknown. Here we provide the experimental evidence that EBV reactivation from latency leads to an increase in the proximity between the <jats:italic>MYC<\/jats:italic> and <jats:italic>IGH<\/jats:italic> loci, otherwise located far away in the nuclear space both in B\u2010lymphoblastoid cell lines and in patients' B\u2010cells. Specific DNA damage within the <jats:italic>MYC<\/jats:italic> locus, followed by the MRE11\u2010dependent DNA repair plays a role in this process. Using a CRISPR\/Cas9\u2010based B cell model to induce specific DNA double strand breaks in <jats:italic>MYC<\/jats:italic> and <jats:italic>IGH<\/jats:italic> loci, we have shown that the <jats:italic>MYC\u2010IGH<\/jats:italic> proximity induced by EBV reactivation leads to an increased t(8;14) translocation frequency.<\/jats:p>","DOI":"10.1002\/jmv.28633","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T10:15:47Z","timestamp":1677838547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Epstein\u2212Barr virus reactivation induces <i>MYC\u2010IGH<\/i> spatial proximity and t(8;14) in B cells"],"prefix":"10.1002","volume":"95","author":[{"given":"Fatimata Bintou","family":"Sall","sequence":"first","affiliation":[{"name":"UMR9018, Universit\u00e9 Paris\u2010Saclay, CNRS, Gustave Roussy Villejuif France"},{"name":"Faculty of Medicine, Pharmacy and Odontology Cheikh Anta Diop 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