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Smallpox vaccines demonstrated high efficacy against MPXVs in the past and are considered a crucial outbreak control measure. However, viruses isolated during the current outbreak carry distinct genetic variations, and the cross\u2010neutralizing capability of antibodies remains to be assessed. Here we report that serum antibodies elicited by first\u2010generation smallpox vaccines can neutralize the current MPXV more than 40 years after vaccine administration.<\/jats:p>","DOI":"10.1002\/jmv.28643","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:06:46Z","timestamp":1678338406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Smallpox vaccination\u2010elicited antibodies cross\u2010neutralize 2022\u2010Monkeypox virus Clade II"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-3147","authenticated-orcid":false,"given":"Elena","family":"Criscuolo","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology and Virology Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-5024","authenticated-orcid":false,"given":"Benedetta","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8232-5786","authenticated-orcid":false,"given":"Roberto","family":"Ferrarese","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-6800","authenticated-orcid":false,"given":"Davide","family":"Ferrari","sequence":"additional","affiliation":[{"name":"SCVSA Department University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Locatelli","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Clementi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Synlab Italia  Castenedolo (BS) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-0910","authenticated-orcid":false,"given":"Nicasio","family":"Mancini","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"IRCCS San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-9861","authenticated-orcid":false,"given":"Nicola","family":"Clementi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"IRCCS San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010141"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011720"},{"key":"e_1_2_10_4_1","unstructured":"Centers for Disease Control and Prevention (CDC). 2022 Global map & case count. 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