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However, the precise mechanism involved in host sensing of IFN\u2010I signaling priming is particularly complex and remains incompletely resolved. This research identified F\u2010box protein 11 (FBXO11), a component of the E3\u2010ubiquitin ligase SKP\/Cullin\/F\u2010box\u00a0complex, acted as an important regulator of IFN\u2010I signaling priming and antiviral process against several RNA\/DNA viruses. FBXO11 functioned as an essential enhancer of IFN\u2010I signaling by promoting the phosphorylation of TBK1 and IRF3. Mechanistically, FBXO11 facilitated the assembly of TRAF3\u2013TBK1\u2013IRF3 complex by mediating the K63 ubiquitination of TRAF3 in a NEDD8\u2010dependent manner to amplify the activation of IFN\u2010I signaling. Consistently, the NEDD8\u2010activating enzyme inhibitor MLN4921 could act as a blocker for FBXO11\u2013TRAF3\u2013IFN\u2010I axis of signaling. More significantly, examination of clinical samples of chronic\u00a0hepatitis B virus\u00a0(HBV) infection and public transcriptome database of severe acute respiratory syndrome coronavirus\u20102\u2010, HBV\u2010, and hepatitis C virus\u2010infected human samples revealed that FBXO11 expression was positively correlated with the stage of disease course. Taken together, these findings suggest that FBXO11 is an amplifier of antiviral immune responses and might serve as a potential therapeutic target for a number of different viral diseases.<\/jats:p>","DOI":"10.1002\/jmv.28655","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T13:10:12Z","timestamp":1678453812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3\u2013TBK1\u2013IRF3 complex"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-1742","authenticated-orcid":false,"given":"Long","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Institute of Systems Medicine Chinese Academy of Medical Sciences &amp; Peking 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