{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:56Z","timestamp":1786978196694,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hand, foot, and mouth disease (HFMD) is a common pediatric infectious illness caused by enteroviruses (EVs). EV\u2010A serotypes are the main pathogens associated with HFMD. In this study, 213 stool samples from 213 children with severe HFMD in Yunnan, China in 2013, 2015, and 2016 were further analyzed retrospectively for EV\u2010B infection. A total of 70.0% of the specimens tested positive for EV.20 EV serotypes were detected. The predominant serotype was enterovirus A71 (EV\u2010A71, 27.7%), followed by coxsackievirus B4 (CV\u2010B4, 16.4%), CV\u2010A16 (9.9%), CV\u2010B5 (6.6%), and Echovirus 9 (E\u20109,4.7%). EV\u2010A and EV\u2010B accounted for 45.1% and 41.3%, respectively. Among the positive specimens, 28.6% were CV\u2010Bs. Co\u2010infection was present in 19.3% of these cases. In the study, CV\u2010B5 and the majority of CV\u2010B4 isolates belonged to genotypes VI and C3, respectively. This result indicates that EV\u2010B, especially CV\u2010Bs, might be the important agents associated with HFMD and this knowledge will contribute to the prevention and treatment of the disease.<\/jats:p>","DOI":"10.1002\/jmv.28669","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T07:44:37Z","timestamp":1678693477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Coxsackievirus B: The important agent of hand, foot, and mouth disease"],"prefix":"10.1002","volume":"95","author":[{"given":"Yuhan","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College Kunming People's Republic of China"},{"name":"Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming People's Republic of 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