{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:02:49Z","timestamp":1791925369571,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Antiviral drugs are not known for drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. The current study aims is to find out the association of antiviral drugs and their possible mechanism with DRESS.\u00a0Data mining algorithms\u00a0such as proportional reporting ratio that is, PRR (\u22652) with associated <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0value (&gt;4), reporting odds ratio that is, ROR (\u22652) with 95% confidence interval and case count (\u22653) were calculated to identify a possible signal. Further, molecular docking studies were conducted to check the interaction of selected antiviral drugs with possible targets.\u00a0The potential signal of DRESS was found to be associated with abacavir, acyclovir, ganciclovir, lamivudine, lopinavir, nevirapine, ribavirin, ritonavir, and zidovudine among all selected antiviral drugs. Further, subgroup analysis has also shown a potential signal in different age groups and gender. The sensitivity analysis results have shown a decrease in the strength of the signal, however, there was no significant impact on the outcome except for acyclovir. The docking results have indicated the possible involvement of human leukocyte antigen\u00a0(HLA)*B1502 and HLA*B5801.\u00a0The positive signal of DRESS was found with selected antiviral drugs except for acyclovir.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28671","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:18:46Z","timestamp":1678796326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Association of antiviral drugs and their possible mechanisms with DRESS syndrome using data mining algorithms"],"prefix":"10.1002","volume":"95","author":[{"given":"Akash","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Clinical Research Delhi Pharmaceutical Sciences and Research University (DPSRU) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Delhi Pharmaceutical Sciences and Research University (DPSRU) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Centre for Precision Medicine and Pharmacy Delhi Pharmaceutical Sciences and Research University (DPSRU) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Delhi Pharmaceutical Sciences and Research University (DPSRU) New Delhi India"},{"name":"Department of Pharmacology Delhi Pharmaceutical Sciences and Research University (DPSRU) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Practical aspects of signal detection in pharmacovigilance. 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