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Having emerged suddenly in 2017, the prevailing opinion is that the virus originated from HKU2, an alphacoronavirus whose primary host is bats, and at some unknown point achieved interspecies transmission via some intermediate. Here, we further explore the evolutionary history and possible cross\u2010species transmission event for SADS\u2010CoV. Coevolutionary analysis demonstrated that HKU2 may have achieved host switch via SADS\u2010related (SADSr)\u2010CoV, which was isolated from the genus <jats:italic>Rhinolophus<\/jats:italic> in 2017. SADS\u2010CoV, HKU2, and SADSr\u2010CoV share similar codon usage patterns and showed a lower tendency to use CpG, which may reflect a method of immune escape. The analyses of virus\u2010host coevolution and recombination support SADSr\u2010CoV is the direct source of SADS\u2010CoV that may have undergone recombination events during its formation. Structure\u2010based spike glycoprotein variance analysis revealed a more nuanced evolutionary pathway to receptor recognition for host switch. We did not find a possible positive selection site, and the dN\/dS of the S gene was only 0.29, which indicates that the current SADS\u2010CoV is slowly evolving. These results provide new insights that may help predict future cross\u2010species transmission, and possibly surveil future zoonotic outbreaks and associated public health emergencies.<\/jats:p>","DOI":"10.1002\/jmv.28672","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:34:38Z","timestamp":1678797278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The origin and evolution of emerged swine acute diarrhea syndrome coronavirus with zoonotic potential"],"prefix":"10.1002","volume":"95","author":[{"given":"De","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang\u2010Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Zhejiang University Hangzhou 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