{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:58:12Z","timestamp":1753869492624,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human influenza A\/H2N2 can induce a pandemic in the future. This study evaluated the hemagglutination inhibition and neutralizing titers of intravenous immunoglobulin against A\/H2N2 viruses, indicating the status of the donor population. In this study, the antibody titers decreased during the study period\u20142012\u20132021\u2014suggesting a reduction in the immunity of the studied population.<\/jats:p>","DOI":"10.1002\/jmv.28685","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T10:36:01Z","timestamp":1679308561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decline in intravenous immunoglobulin titer against influenza virus A\/H2N2 derived from donors in Japan"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-5894","authenticated-orcid":false,"given":"Mikihiro","family":"Yunoki","sequence":"first","affiliation":[{"name":"R&amp;D Division Japan Blood Products Organization Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Kubota\u2010Koketsu","sequence":"additional","affiliation":[{"name":"Department of Viral Infections, Research Institute for Microbial Diseases Osaka University Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shioda","sequence":"additional","affiliation":[{"name":"Department of Viral Infections, Research Institute for Microbial Diseases Osaka University Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens5040066"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1201.051254"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy291"},{"key":"e_1_2_9_5_1","unstructured":"Statistics Bureau Japan. Population Estimates by Age (Five\u2010Year Groups) and Sex \u2010 November 1 2021 (Final estimates) April 1 2022 (Provisional estimates) [cited July 11 2022].https:\/\/www.e-stat.go.jp\/en\/stat-search\/files?page=1&layout=datalist&toukei=00200524&tstat=000000090001&cycle=1&year=20220&month=12040604&tclass1=000001011678"},{"key":"e_1_2_9_6_1","first-page":"245","article-title":"Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010","volume":"6","author":"Kubota\u2010Koketsu R","year":"2012","journal-title":"Biologics"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.5.2552-2558.1993"},{"key":"e_1_2_9_8_1","first-page":"253","article-title":"Development of polyethylene glycol treated human immunoglobulin which introduced with 19 nm viral removal filtration process","volume":"56","author":"Kawabata Y","year":"2007","journal-title":"J New Rem Clin"},{"key":"e_1_2_9_9_1","unstructured":"Japanese Red Cross. Blood Business in Japan by the Numbers [cited 24 May 2022].https:\/\/www.jrc.or.jp\/donation\/blood\/data\/[In Japanese]."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1510.081668"},{"key":"e_1_2_9_11_1","first-page":"99","article-title":"Neutralizing activities of human immunoglobulin derived from donors in Japan against mosquito\u2010borne flaviviruses, Japanese encephalitis virus, West Nile virus, and dengue virus","volume":"10","author":"Yunoki M","year":"2016","journal-title":"Biologics"},{"key":"e_1_2_9_12_1","first-page":"217","article-title":"Heterosubtypic anti\u2010avian H5N1 influenza antibodies in intravenous immunoglobulins from globally separate populations protect against H5N1 infection in cell culture","volume":"3","author":"Sullivan JS","year":"2009","journal-title":"J Mol Genet Med"},{"key":"e_1_2_9_13_1","first-page":"87","article-title":"Virus neutralization by human intravenous immunoglobulin against influenza virus subtypes A\/H5 and A\/H7","volume":"15","author":"Kubota\u2010Koketsu R","year":"2021","journal-title":"Biologics"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05397-11"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.786617"},{"key":"e_1_2_9_16_1","unstructured":"Ministry of Health Labour and Welfare Japan. Supply of Influenza Vaccine for the 2022\/2011 Season [cited August 31 2022].https:\/\/www.mhlw.go.jp\/content\/10906000\/000982566.pdf[In Japanese]."},{"key":"e_1_2_9_17_1","unstructured":"National Institute for Infectious Diseases Japan. Situations of influenza vaccination and seroprevalence in the 2019 Infectious Disease Epidemic Projection Survey [cited December 20 2020].https:\/\/www.niid.go.jp\/niid\/ja\/typhi-m\/iasr-reference\/2530-related-articles\/related-articles-489\/9965-489r04.html[In Japanese]."}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:32:03Z","timestamp":1692649923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/jmv.28685"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28685","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28685"}}