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For a country with a large population like India, all the three strategies can be a challenge. There is a need for implementation of a high throughput technology that can be scalable. Cobas 4800, a multiplexed assay based on quantitative polymerase chain reaction technology, identifies HPV 16 and HPV 18 along with the concurrent detection of 12 pooled other high\u2010risk HPV infections. This technology was used to test 10\u2009375 women from the South Indian community for the first time as a feasibility program. Upon testing, high\u2010risk HPV was found in 595 (5.73%) women. A total of 127 women (1.2%) were found to be infected with HPV 16, 36 women (0.34%) with HPV 18 and 382 women (3.68%) with the 12 pooled high\u2010risk HPV and multiple mixed infections were found in 50 women (0.48%). It was observed that there was a high prevalence of high\u2010risk HPV in younger women, 30\u201340 years of age and a second peak was observed at 46\u201350 years of age. The second peak had higher mixed infections in the 46\u201350 years of age and this association was statistically significant. We found that 24\/50 (48%) of the multiple mixed high\u2010risk HPV infections were in the age group 46\u201350 years. The current study is the first attempt from India, on a completely automated platform using Cobas 4800 HPV test in a community screening program. This study shows HPV 16 and HPV 18 infections, when differentiated, can be valuable for risk stratification in community screening program. Women in the perimenopausal age (46\u201050yrs) showed a higher prevalence of multiple mixed infections, signifying a higher risk.<\/jats:p>","DOI":"10.1002\/jmv.28715","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T10:03:35Z","timestamp":1681121015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of HPV molecular testing with partial genotyping as a feasibility study in cervical cancer community screening program in South India"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-0806","authenticated-orcid":false,"given":"Vijayalakshmi","family":"Ramshankar","sequence":"first","affiliation":[{"name":"Department of Preventive Oncology (Research) Cancer Institute (WIA), Adyar Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soundharya","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Preventive Oncology (Research) Cancer Institute (WIA), Adyar Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komathi","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Preventive Oncology (Research) Cancer Institute (WIA), Adyar Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Preventive Oncology (Research) Cancer Institute (WIA), Adyar Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakthi Lalitha","family":"Sri","sequence":"additional","affiliation":[{"name":"Department of Preventive Oncology (Research) Cancer Institute (WIA), Adyar Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Ramasubramanian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Government Thoothukudi Medical College Hospital Thoothukudi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banumathy","family":"Satyaseelan","sequence":"additional","affiliation":[{"name":"Sushrushah Hospital Nagercoil India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer (IARC) TIA for R on.Global cancer observatory. 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