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However, limited studies were conducted to explore the potential interaction effects of inflammation and coronavirus disease 2019 (COVID\u201019) on the risks of anxiety and depression. In this study, first, polygenic risk scores (PRS) were calculated for eight COVID\u201019 clinical phenotypes using individual\u2010level genotype data from the UK Biobank. Then, linear regression models were developed to assess the effects of COVID\u201019 PRS, C\u2010reactive protein (CRP), systemic immune inflammation index (SII), and their interaction effects on the Generalized Anxiety Disorder\u20107 (GAD\u20107, 104\u2009783 individuals) score and the Patient Health Questionnaire\u20109 (PHQ\u20109, 104\u2009346 individuals) score. Several suggestive interactions between inflammation factors and COVID\u201019 clinical phenotypes were detected for PHQ\u20109 score, such as CRP\/SII\u2009\u00d7\u2009Hospitalized\/Not_Hospitalized in women group and CRP\u2009\u00d7\u2009Hospitalized\/Unscreened in age &gt;65 years group. For GAD\u20107 score, we also found several suggestive interactions, such as CRP\u2009\u00d7\u2009Positive\/Unscreened in the age \u226465 years group. Our results suggest that not only COVID\u201019 and inflammation have important effects on anxiety and depression but also the interactions of COVID\u201019 and inflammation have serious risks for anxiety and depression.<\/jats:p>","DOI":"10.1002\/jmv.28726","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T15:17:05Z","timestamp":1681399025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Retracted:<\/i> Combined effects of inflammation and coronavirus disease 2019 (COVID\u201019) on the risks of anxiety and depression: A cross\u2010sectional study based on UK Biobank"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-4798","authenticated-orcid":false,"given":"Na","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key 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