{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:32:47Z","timestamp":1784842367412,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>People living with HIV (PLWH) have poor outcomes from severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102); vaccination reduces the associated mortality. The humoral immune response dynamics after booster inactivated vaccinations in PLWH remain unclear. In this longitudinal observational study, 100 PLWH after primary inactivated SARS\u2010CoV\u20102 vaccination were consecutively recruited and followed up. After booster vaccination (BV), neutralizing antibodies (NAbs) were detected at 1 month from all the PLWH, and the titer increased sixfold compared to that associated with the primary vaccination (PV), similar to that in healthy controls after BV. The\u00a0NAbs titer declined over time after BV, but remained higher at 6 months than after PV. The NAbs response was elevated after BV with CD4 count &lt;200 cells\/\u03bcL, it was the poorest among the different CD4 cell\u00a0count subgroups. Similar results were observed for anti\u2010RBD\u2010IgG responses. Moreover, RBD\u2010specific MBCs were significantly elevated after BV in PLWH. No serious AEs were observed after BV in PLWH. In conclusion, booster inactivated SARS\u2010CoV\u20102 vaccination is well tolerated and can elicit robust and durable humoral responses in PLWH. PLWH may benefit from a third dose of the inactivated vaccine.<\/jats:p>","DOI":"10.1002\/jmv.28730","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T13:10:25Z","timestamp":1681477825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic immunogenicity after primary and booster inactivated SARS\u2010CoV\u20102 vaccination in people living with HIV: A longitudinal observational study"],"prefix":"10.1002","volume":"95","author":[{"given":"Ting","family":"Lu","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis The Second Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"The People's Hospital of Tongliang District Chongqing 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