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High levels of numerous crucial pro\u2010inflammatory cytokines, such as interleukin\u20101\u00a0(IL\u20101), IL\u20102, IL\u20106, tumor necrosis factor\u2010\u03b1, interferon\u00a0(IFN)\u2010\u03b3,\u00a0IFN\u2010induced protein 10\u2009kDa, granulocyte\u2010macrophage colony\u2010stimulating factor,\u00a0monocyte chemoattractant protein\u20101, and IL\u201010 and so on, have been found in severe COVID\u201019. They participate in cascade amplification pathways of pro\u2010inflammatory responses through complex inflammatory networks. Here, we review the involvements of these critical inflammatory cytokines in SARS\u2010CoV\u20102 infection and discuss their potential roles in triggering or regulating cytokine storm, which can help to understand the pathogenesis of severe COVID\u201019. So far, there is rarely effective therapeutic strategy for patients with cytokine storm besides using glucocorticoids, which is proved to result in fatal side effects. Clarifying the roles of key involved cytokines in the complex inflammatory network of cytokine storm will help to develop an ideal therapeutic intervention, such as neutralizing antibody of certain cytokine or inhibitor of some inflammatory signal pathways.<\/jats:p>","DOI":"10.1002\/jmv.28751","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T16:15:27Z","timestamp":1682439327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The roles of critical pro\u2010inflammatory cytokines in the drive of cytokine storm during SARS\u2010CoV\u20102 infection"],"prefix":"10.1002","volume":"95","author":[{"given":"Muhammad Suhaib","family":"Qudus","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences Wuhan University Wuhan 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