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Leveraging large\u2010scale genome\u2010wide association study (GWAS)\u00a0summary statistics, we investigated the genetic correlation and causal relationship between genetically determined vitamin D and COVID\u201019 using linkage disequilibrium score\u00a0regression and Mendelian randomization (MR)\u00a0analyses, and conducted a cross\u2010trait GWAS meta\u2010analysis to identify the overlapping susceptibility loci of them. We observed a significant genetic correlation between genetically predicted vitamin D and COVID\u201019\u00a0(<jats:italic>r<\/jats:italic><jats:sub><jats:italic>g<\/jats:italic><\/jats:sub>\u2009=\u2009\u22120.143, <jats:italic>p<\/jats:italic>\u2009=\u20090.011), and the risk of COVID\u201019\u00a0infection would decrease by 6% for every 0.76\u2009nmol\u2009L<jats:sup>\u22121<\/jats:sup> increase of serum 25 hydroxyvitamin D (25OHD)\u00a0concentrations in generalized MR (OR\u2009=\u20090.94, 95%\u00a0CI: 0.89\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). We identified rs4971066 (<jats:italic>EFNA1<\/jats:italic>) as a risk locus for the joint phenotype of vitamin D and COVID\u201019.\u00a0In conclusion, genetically determined vitamin D is associated with COVID\u201019. Increased levels of serum 25OHD concentration may benefit the prevention and treatment of COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.28780","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T16:58:15Z","timestamp":1683997095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genetic correlation, causal relationship, and shared loci between vitamin D and COVID\u201019: A genome\u2010wide cross\u2010trait analysis"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-4199","authenticated-orcid":false,"given":"Shizheng","family":"Qiu","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology Harbin Institute of Technology Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Harbin 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