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However, Gansu province in Western China experienced the largest JE outbreak since 1958 in 2018. We conducted a retrospective epidemiological study to explore the causes of this outbreak. We found that adults aged \u226520 years (especially those in rural areas) were the main JE cases in Gansu Province, with a significant increase in the JE incidence in older adults aged \u226560 years in 2017 and 2018. In addition, JE outbreaks in Gansu Province were mainly located in the southeastern region, while the temperature and precipitation in Gansu Province were gradually increasing in recent years, which made the JE epidemic areas in Gansu Province gradually spread to the western of Gansu Province. We also found that adults aged \u226520 years in Gansu Province had lower JE antibody positivity than children and infants, and the antibody positivity rate decreased with age. In the summer of 2017 and 2018, the density of mosquitoes (mainly the <jats:italic>Culex tritaeniorhynchus<\/jats:italic>) in Gansu Province was significantly higher than in other years, and the genotype of JEV was mainly Genotype\u2010G1. Therefore, in the future JE control in Gansu Province, we need to strengthen JE vaccination for adults. Moreover, strengthening mosquito surveillance can provide early warning of JE outbreaks and the spread of epidemic areas in Gansu Province. At the same time, strengthening JE antibody surveillance is also necessary for JE control.<\/jats:p>","DOI":"10.1002\/jmv.28782","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T08:28:57Z","timestamp":1683620937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adults in Northwest China experienced the largest outbreak of Japanese encephalitis in history 10 years after the Japanese encephalitis vaccine was included in the national immunization program: A retrospective epidemiological study"],"prefix":"10.1002","volume":"95","author":[{"given":"Xiaoshu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Immunization Program Gansu Provincial Center for Disease Control and Prevention Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Immunization 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