{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:35:54Z","timestamp":1787510154758,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intranasal (i.n.) vaccines can induce mucosal and systemic immunity against respiratory pathogens. Previously, we demonstrated that the recombinant vesicular stomatitis virus (rVSV)\u2010based COVID\u201019 vaccine rVSV\u2010SARS\u2010CoV\u20102, with poor immunogenicity via the intramuscular route (i.m.), is more suitable for i.n. administration in mice and nonhuman primates. Here, we found that the rVSV\u2010SARS\u2010CoV\u20102 Beta variant was more immunogenic than the wild\u2010type strain and other variants of concern (VOCs) in golden Syrian hamsters. Furthermore, the immune responses elicited by rVSV\u2010based vaccine candidates via the i.n. route were\u00a0significantly higher than those\u00a0of two licensed vaccines:\u00a0the inactivated vaccine KCONVAC delivered via the i.m. route and the adenovirus\u2010based Vaxzevria delivered i.n. or i.m. We next assessed the booster efficacy of rVSV following two i.m. doses of KCONVAC. Twenty\u2010eight days after receiving two i.m. doses of KCONVAC, hamsters were boosted with a third dose of KCONVAC (i.m.), Vaxzevria (i.m. or i.n.), or rVSVs (i.n.). Consistent with other heterologous booster studies, Vaxzevria and rVSV elicited significantly higher humoral immunity than the homogenous KCONVAC. In summary, our results confirmed that two i.n. doses of rVSV\u2010Beta elicited significantly higher humoral immune responses than commercial inactivated and adeno\u2010based COVID vaccines in hamsters. As a heterologous booster dose, rVSV\u2010Beta induced potent, persistent, and broad\u2010spectrum humoral and mucosal neutralizing responses against all VOCs, highlighting its potential to be developed into a nasal\u2010spray vaccine.<\/jats:p>","DOI":"10.1002\/jmv.28806","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T08:21:11Z","timestamp":1684830071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of the immunogenicity of nasal\u2010spray rVSV vector, adenovirus vector, and inactivated COVID\u201019\u2010based vaccines in rodent models"],"prefix":"10.1002","volume":"95","author":[{"given":"Yuhang","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences Beijing China"},{"name":"CAS Center for Excellence in Biotic Interactions University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Minhai Biotechnology Co., Ltd. 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