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A total of 100 patients diagnosed with AR\u2010DLBCL were enrolled in our study. Clinical features and prognostic factors for overall survival (OS) and progression\u2010free survival (PFS) were evaluated by univariate and multivariate analyses. Central nervous system (CNS) involvement, opportunistic infection (OI) at lymphoma diagnosis, and elevated lactate dehydrogenase (LDH) were selected to construct the OS model; CNS involvement, OI at lymphoma diagnosis, elevated LDH, and over four\u00a0chemotherapy cycles were selected to construct the PFS model. The area under the curve\u00a0and C\u2010index of GZMU OS and PFS models were 0.786\/0.712; 0.829\/0.733, respectively. The models we constructed showed better risk stratification than International Prognostic Index\u00a0(IPI), age\u2010adjusted\u00a0IPI, and National Comprehensive Cancer Network\u2010IPI. Furthermore, in combined cohort, the Hosmer\u2212Lemeshow test showed that the models were good fits (OS: <jats:italic>p<\/jats:italic>\u2009=\u20090.8244; PFS: <jats:italic>p<\/jats:italic>\u2009=\u20090.9968) and the decision curve analysis\u00a0demonstrated a significantly better net benefit. The prognostic efficacy of the proposed models was validated independently and outperformed the currently available prognostic tools. These novel prognostic models will help to tackle a clinically relevant unmet need.<\/jats:p>","DOI":"10.1002\/jmv.28821","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T12:10:24Z","timestamp":1685016624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Construction and validation of prognostic scoring models to risk stratify patients with acquired immune deficiency syndrome\u2010related diffuse large B cell lymphoma"],"prefix":"10.1002","volume":"95","author":[{"given":"Han","family":"Zhao","sequence":"first","affiliation":[{"name":"Infectious Diseases Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-9274","authenticated-orcid":false,"given":"Rongqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology 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