{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:17:45Z","timestamp":1792581465568,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in children and adolescents may increase risk for a variety of post\u2010acute sequelae including new\u2010onset type 1 diabetes mellitus (T1DM). Therefore, this meta\u2010analysis aims to estimate the risk of developing new\u2010onset type 1 diabetes in children and adolescents as post\u2010acute sequelae of SARS\u2010CoV\u20102 infection.\u00a0PubMed\/MEDLINE, CENTRAL, and EMBASE were systematically searched up to March 20, 2023. A systematic review and subsequent meta\u2010analyses were performed to calculate the pooled effect size, expressed as risk ratio (RR) with corresponding 95% confidence interval (CI) of each outcome based on a one\u2010stage approach and the random\u2010effects estimate of the pooled effect sizes of each outcome were generated with the use of the DerSimonian\u2010Laird method.\u00a0Eight reports from seven studies involving 11\u2009220\u2009530 participants (2\u2009140\u2009897 patients with a history of diagnosed SARS\u2010CoV\u20102 infection and 9\u2009079\u2009633 participants in the respective control groups) were included. The included studies reported data from four U.S. medical claims databases covering more than 503 million patients (IQVIA, HealthVerity, TriNetX, and Cerner Real\u2010World Data), and three national health registries for all children and adolescents in Norway, Scotland, and Denmark. It was shown that the risk of new\u2010onset T1DM following SARS\u2010CoV\u20102 infection in children and adolescents was 42% (95% CI 13%\u221277%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) higher compared with non\u2010COVID\u201019 control groups. The risk of developing new\u2010onset T1DM following SARS\u2010CoV\u20102 infection was significantly higher (67%, 95% CI 32 %\u2013112%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001) in children and adolescents between 0 and 11 years, but not in those between 12 and 17 years (RR\u2009=\u20091.10, 95% CI 0.54\u20132.23, <jats:italic>p<\/jats:italic>\u2009=\u20090.79). We also found that the higher risk for developing new\u2010onset T1DM following SARS\u2010CoV\u20102 infection only exists in studies from the United States (RR\u2009=\u20091.70, 95% CI 1.37\u22122.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.00001) but not Europe (RR\u2009=\u20091.02, 95% CI 0.67\u22121.55, <jats:italic>p<\/jats:italic>\u2009=\u20090.93). Furthermore, we found that SARS\u2010CoV\u20102 infection was associated with an elevation in the risk of diabetic ketoacidosis (DKA) in children and adolescents compared with non\u2010COVID\u201019 control groups (RR\u2009=\u20092.56, 95% CI 1.07\u22126.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.03).\u00a0Our findings mainly obtained from US\u00a0medical claims databases, suggest that SARS\u2010CoV\u20102 infection is associated with higher risk of developing new\u2010onset T1DM and diabetic ketoacidosis in children and adolescents. These findings highlight the need for targeted measures to raise public health practitioners and physician awareness to provide intervention strategies to reduce the risk of developing T1DM in children and adolescents who have had COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.28833","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T13:10:56Z","timestamp":1685711456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["New\u2010onset type 1 diabetes in children and adolescents as postacute sequelae of SARS\u2010CoV\u20102 infection: A systematic review and meta\u2010analysis of cohort studies"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-027X","authenticated-orcid":false,"given":"Masoud","family":"Rahmati","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sport Sciences, Faculty of Literature and Human 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