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The currently fast\u2010spreading Omicron variant that manifests without symptoms or with upper respiratory diseases has been recognized as a serious global public health problem. However, its pathological mechanism is largely unknown. In this work, rhesus macaques, hamsters, and BALB\/C\u00a0mice were employed as animal models to explore the pathogenesis of Omicron (B.1.1.529). Notably, Omicron (B.1.1.529) infected the nasal turbinates, tracheae, bronchi, and lungs of hamsters and BALB\/C\u00a0mice with higher viral loads than in those of rhesus macaques. Severe histopathological damage and inflammatory responses were observed in the lungs of Omicron (B.1.1.529)\u2010infected animals. In addition, viral replication was found in multiple extrapulmonary organs. Results indicated that hamsters and BALB\/c\u00a0mice are potential animal models for studies on the development of drugs\/vaccines and therapies for Omicron (B.1.1.529).<\/jats:p>","DOI":"10.1002\/jmv.28846","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:26:37Z","timestamp":1686194797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SARS\u2010CoV\u20102 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB\/c mice with severe lung histopathological damage"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-2062","authenticated-orcid":false,"given":"Wenhai","family":"Yu","sequence":"first","affiliation":[{"name":"National Kunming High\u2010level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan 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