{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:26:17Z","timestamp":1776471977469,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tecovirimat is a treatment option for severe mpox, although randomized clinical trials are ongoing. The aim of the study is to assess the effect of tecovirimat on healing time and the extent of viral clearance by target trial emulation using observational data. Clinical and virological data of patients hospitalized for mpox were collected. Samples from the upper respiratory tract (URT) were grouped in two time points: T1 (median 6 days from symptoms onset) and T2 (median 5 days from T1). Patients were followed\u2010up until recovery. Average treatment effect (ATE) in patients untreated versus treated with tecovirimat was estimated on time to healing and variation in viral load in URT, using a weighted and cloning analysis. Among the 41 patients included, 19 completed a course of tecovirimat. The median time from symptoms onset to hospitalization and to drug\u2010starting was 4 days and 10 days, respectively. No improvement in healing time in treated versus untreated was observed. No difference by treatment group in time to viral clearance was detected by ATE fitted in a subset of 13 patients after controlling for confounders. We found no evidence for a large effect of tecovirimat in shortening healing time and viral clearance. While awaiting the results of randomized studies, the use of tecovirimat should be restricted to the clinical trial setting.<\/jats:p>","DOI":"10.1002\/jmv.28868","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T11:59:22Z","timestamp":1686571162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of tecovirimat on healing time and viral clearance by emulation of a target trial in patients hospitalized for mpox"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-7504","authenticated-orcid":false,"given":"Valentina","family":"Mazzotta","sequence":"first","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"},{"name":"Doctoral School of Microbiology, Immunology, Infectious Diseases, and Transplants (MIMIT) University of Rome Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cozzi\u2010Lepri","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, Epidemiology, Modelling, and Evaluation (CREME) Institute for Global Health, UCL London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Lanini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-2610","authenticated-orcid":false,"given":"Annalisa","family":"Mondi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Carletti","sequence":"additional","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Tavelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Gagliardini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Vita","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National 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IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Faccendini","sequence":"additional","affiliation":[{"name":"Pharmacy Unit National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Matusali","sequence":"additional","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Faraglia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Beccacece","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Vaia","sequence":"additional","affiliation":[{"name":"General Direction National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Maggi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Antinori","sequence":"additional","affiliation":[{"name":"Department of Clinical and Research Infectious Diseases National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO. Second meeting of the International Health Regulations (2005) (IHR) Emergency Committee regarding the multi\u2010country outbreak of monkeypox. July 23 2022.https:\/\/www.who.int\/news\/item\/23-07-2022-second-meeting-of-the-international-health-regulations-(2005)-(ihr)-emergency-committee-regarding-the-multi-country-outbreak-of-monkeypox"},{"key":"e_1_2_10_3_1","unstructured":"Centers and Disease Control and Prevention: 2022 Monkeypox Outbreak Global Map.2023 5:30 PM EDT Data as of 29 Jan. Accessed January 31 2023.https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/response\/2022\/world-map.html"},{"key":"e_1_2_10_4_1","unstructured":"Centers and Disease Control and Prevention: Interim Clinical Guidance for the Treatment of Monkeypox. Updated October 31 2022. Accessed January 31 2023.https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/clinicians\/treatment.html"},{"key":"e_1_2_10_5_1","unstructured":"Highlights of Prescribing Information (TPOXX). Food and Drug Administration. Updated May 2022. 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