{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:52:45Z","timestamp":1793677965132,"version":"4.5.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe fever with thrombocytopenia syndrome virus (SFTSV) and severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) can cause the hyperproduction of inflammatory cytokines, which have pathological effects in patient including severe or fatal cytokine storms. To characterize the effect of SFTSV and SARS\u2010CoV\u20102 infection on the production of cytokines in severe fever with thrombocytopenia syndrome (SFTS) and COVID\u201019 patients, we performed an analysis of cytokines in SFTS and COVID\u201019 patients and also investigated the role of interleukin\u201010 (IL\u201010) in vitro studies: lipopolysaccharide\u2010induced THP\u20101\u2010derived macrophages, SFTSV infection of THP\u20101 cells, and SARS\u2010CoV\u20102 infection of THP\u20101 cells. In this study, we found that levels of both IL\u201010 and IL\u20106 were significantly elevated, the level of transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) was significantly decreased and IL\u201010 was elevated earlier than IL\u20106 in severe and critical COVID\u201019 and fatal SFTS patients, and inhibition of IL\u201010 signaling decreased the production of IL\u20106 and elevated that of TGF\u2010\u03b2. Therefore, the hyperproduction of IL\u201010 and IL\u20106 and the low production of TGF\u2010\u03b2 have been linked to cytokine storm\u2010induced mortality in fatal SFTS and severe and critically ill COVID\u201019 patients and that IL\u201010 can play an important role in the host immune response to severe and critical SARS\u2010CoV\u20102 and fatal SFTSV infection.<\/jats:p>","DOI":"10.1002\/jmv.28894","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T07:19:22Z","timestamp":1688109562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID\u201019 is associated with the hyperproduction of IL\u201010 and IL\u20106 and the low production of TGF\u2010\u03b2"],"prefix":"10.1002","volume":"95","author":[{"given":"Su Yeon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine Hanyang University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Rae","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Jeju National University Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Taek","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Jeju National University Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine Hanyang University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Jeju National University Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Radiation Biomedical Research Korea Institute of Radiological and Medical Science Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhyeok","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine 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