{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:30:25Z","timestamp":1781976625501,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The association between SARS\u2010CoV\u20102 infection with increased risk for new\u2010onset neurodegenerative diseases remains unclear. Therefore, this meta\u2010analysis aims to elucidate whether new\u2010onset neurodegenerative diseases are long\u2010term sequelae of SARS\u2010CoV\u20102 infection.\u00a0PubMed\/MEDLINE, CENTRAL, and EMBASE were systematically searched for articles published up to\u00a0January 10, 2023. A systematic review and meta\u2010analysis were performed to calculate the pooled effect size, expressed as hazard ratios (HR) with corresponding 95% confidence interval (CI) of each outcome.\u00a0Twelve studies involving 33\u2009146\u2009809 individuals (2\u2009688\u2009417 post\u2010COVID\u201019 cases and 30\u2009458\u2009392 controls) were included in the present meta\u2010analysis. The pooled analyses compared with control groups showed a significant association between SARS\u2010CoV\u20102 infection and increased risk for new\u2010onset Alzheimer's disease (HR\u2009=\u20091.50, 95% CI 1.22\u20131.85, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200997%), dementia (HR\u2009=\u20091.66, 95% CI 1.42\u20131.94, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200991%), and Parkinson's disease (HR\u2009=\u20091.44, 95% CI 1.06\u20131.95, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200986%) among COVID\u201019 survivors.\u00a0SARS\u2010CoV\u20102 infection may be associated with a higher risk for new\u2010onset neurodegenerative diseases in recovered COVID\u201019 patients. Future studies are warranted to determine the biological mechanisms underlying the neurodegenerative consequences of COVID\u201019 as long\u2010term sequelae of SARS\u2010CoV\u20102 infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28909","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T05:19:37Z","timestamp":1688361577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["New\u2010onset neurodegenerative diseases as long\u2010term sequelae of SARS\u2010CoV\u20102 infection: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-027X","authenticated-orcid":false,"given":"Masoud","family":"Rahmati","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences Lorestan University Khoramabad 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