{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:20Z","timestamp":1753869440842,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human adenoviruses (HAdVs) of the F species are commonly responsible for acute gastroenteritis. A few cases of systemic infections have been described in adults or children who have received a hematopoietic stem cell transplant (HSCT), but with no report of liver cytolysis. Since January 2022, several countries have reported an increase in cases of acute hepatitis of unknown cause in children. Adenovirus species F type 41 (HAdV\u2010F41)\u00a0infection was predominantly identified. The objective of this study is to describe HAdV\u2010F41 infections diagnosed since January 2022 in adult HSCT recipients in two French hospitals. All four patients had diarrhea and liver cytolysis at the time of diagnosis of infection. HAdV viremia was observed in three patients (#1, #3, and #4), but no disseminated disease was reported. HAdV whole genome sequencing and metagenomics characterization were performed on stool and blood samples. The complete HAdV\u2010F41 genome sequence was obtained for three patients and phylogenetic analysis showed that the strains consisted of similar lineage (2b). We did not identify any new HAdV\u2010F41 strains. Metagenomics analysis found adeno\u2010associated virus 2 and torque\u2010teno virus infection in patient #1 and Epstein\u2013Barr virus in patient #4. This is the first case series reporting liver cytolysis during HAdV\u2010F41 infection in adult HSCT patients.<\/jats:p>","DOI":"10.1002\/jmv.28922","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T07:38:50Z","timestamp":1688110730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenovirus F41 infection and liver cytolysis in adult hematopoietic stem cell transplant recipients"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4934-5926","authenticated-orcid":false,"given":"Caroline","family":"Lefeuvre","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie CHU Angers Angers France"},{"name":"Univ Angers, HIFIH, SFR ICAT Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Thepot","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CHU Angers Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Mercier\u2010Delarue","sequence":"additional","affiliation":[{"name":"Virologie, AP\u2010HP, H\u00f4pital Saint Louis Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Bouille","sequence":"additional","affiliation":[{"name":"Virologie, AP\u2010HP, H\u00f4pital Saint Louis Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Michonneau","sequence":"additional","affiliation":[{"name":"H\u00e9matologie \u2010 greffe de moelle, AP\u2010HP, H\u00f4pital Saint Louis Paris France"},{"name":"INSERM U976, Equipe INSIGHT Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Le Goff","sequence":"additional","affiliation":[{"name":"Virologie, AP\u2010HP, H\u00f4pital Saint Louis Paris France"},{"name":"INSERM U976, Equipe INSIGHT Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-6132","authenticated-orcid":false,"given":"Maud","family":"Salmona","sequence":"additional","affiliation":[{"name":"Virologie, AP\u2010HP, H\u00f4pital Saint Louis Paris France"},{"name":"INSERM U976, Equipe INSIGHT Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.15.2200318"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206704"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206294"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2016.09.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24579"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03148-20"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/veac098"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.03.011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5189-5198.2004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.9.3963-3969.2004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy323"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-022-04484-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-022-01905-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.159579"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"HoA OrtonR TaylerR AsamaphanP TongL. 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