{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:23Z","timestamp":1753869443345,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>A proportion of chronic hepatitis B virus (HBV) carriers with normal alanine transaminase\u00a0(ALT) present with significant liver histological changes (SLHC).\u00a0To construct a noninvasive nomogram model to identify SLHC in chronic HBV carriers with different upper limits of normal (ULNs) for ALT.\u00a0The training cohort consisted of 732 chronic HBV carriers who were stratified into four sets according to different ULNs for ALT: chronic HBV carriers I,\u00a0II,\u00a0III,\u00a0and IV. The external validation cohort comprised 277 chronic HBV carriers. Logistic regression and least absolute shrinkage and selection operator\u00a0analyses were applied to develop a nomogram model to predict SLHC.\u00a0A nomogram model\u2010HBGP (based on hepatitis B surface antigen, gamma\u2010glutamyl transpeptidase, and platelet count) demonstrated good performance in diagnosing SLHC with area under the curve\u00a0(AUCs) of 0.866 (95% confidence interval [CI]:\u00a00.839\u22120.892)\u00a0and 0.885 (95% CI:\u00a00.845\u22120.925) in the training and validation cohorts, respectively. Furthermore, HBGP displayed high diagnostic values for SLHC with AUCs of 0.866 (95% CI:\u00a00.839\u22120.892), 0.868 (95% CI:\u00a00.838\u22120.898), 0.865 (95% CI:\u00a00.828\u22120.901), and 0.853 (95% CI:\u00a00.798\u22120.908) in chronic HBV carriers I, II, III, and IV, respectively. Additionally, HBGP showed greater ability in predicting SLHC compared with the existing predictors.\u00a0HBGP has shown high predictive performance for SLHC, and thus may lead to an informed decision on the initiation of antiviral treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28943","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T15:41:11Z","timestamp":1689176471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development a novel nomogram model for predicting significant hepatic histological changes in chronic hepatitis B virus carriers"],"prefix":"10.1002","volume":"95","author":[{"given":"Na\u2010Ling","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Hepatology, Clinical Research Center for Liver and Intestinal Diseases of Fujian Province,\u00a0Hepatology Research Institute, The First Affiliated Hospital Fujian Medical University Fujian 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