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This study aimed to evaluate the relationship between exposure of adult patients to mean 24\u2009h levels of particulate matter sized &lt;10\u2009\u03bcm\u00a0(PM\n                    <jats:sub>10<\/jats:sub>\n                    ) and &lt;2.5\u2009\u03bcm (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) and benzo(a)pyrene (B(a)P) during a week before their hospitalization due to SARS\u2010CoV\u20102 infection and symptomatology, hyperinflammation, coagulopathy, the clinical course of disease, and outcome. The analyses were conducted during two pandemic waves: (i) dominated by highly pathogenic Delta variant (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091440) and (ii) clinically less\u2010severe Omicron (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009785), while the analyzed associations were adjusted for patient's age, BMI, gender, and comorbidities. The exposure to mean 24\u2009h B(a)P exceeding the limits was associated with increased odds of fever and fatigue as early COVID\u201019 symptoms, hyperinflammation due to serum C\u2010reactive protein &gt;200\u2009mg\/L\u00a0and interleukin\u20106 &gt;100\u2009pg\/mL, coagulopathy due to\u00a0\n                    <jats:sc>d<\/jats:sc>\n                    \u2010dimer &gt;2\u2009mg\/L and fatal outcome. Elevated PM\n                    <jats:sub>10<\/jats:sub>\n                    and PM\n                    <jats:sub>2.<\/jats:sub>\n                    <jats:sub>5<\/jats:sub>\n                    levels were associated with higher odds of respiratory symptoms, procalcitonin &gt;0.25\u2009ng\/mL and interleukin &gt;100\u2009pg\/mL, lower oxygen saturation, need for oxygen support, and death. The significant relationships between exposure to air pollutants and the course and outcomes of COVID\u201019 were observed during both pandemic waves. Short\u2010term exposure to elevated PM and B(a)P levels can be associated with a worse clinical course of COVID\u201019 in patients requiring hospitalization and, ultimately, contribute to the health burden caused by SARS\u2010CoV\u20102 variants of higher and lower clinical significance.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28962","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T08:56:22Z","timestamp":1689756982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Short\u2010term exposure to ambient air pollution and COVID\u201019 severity during SARS\u2010CoV\u20102 Delta and Omicron waves: A multicenter study"],"prefix":"10.1002","volume":"95","author":[{"given":"Barbara","family":"Poniedzia\u0142ek","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine Poznan University of Medical Sciences Pozna\u0144 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